ArticlePopulation studies2020
Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda.
Article in Population studies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Hypertension is a marker of the micro-epidemiologic transition in ageing HIV populations in Kenya, Uganda and Tanzania (AFRICOS, 2013-2023).BMC public health · 2026Article
- Incidence and prevalence of orphanhood in Rakai, Uganda: a population-based cohort study, 1995-2022.The Lancet. Global health · 2026Article
- Estimation of cause-specific mortality in Rakai, Uganda, using verbal autopsy 1999-2019.Global health action · 2024Article
- Death after cure: Mortality among pulmonary tuberculosis survivors in rural Uganda.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Experiences and lessons learned from a global research administration capacity building project to support and expand HIV/AIDS research in southwestern Uganda.Discover health systems · 2024Article
- Age Patterns of HSV-2 Incidence and Prevalence in Two Ugandan Communities: A Catalytic Incidence Model Applied to Population-Based Seroprevalence Data.The Journal of infectious diseases · 2023Article
- HIV, tuberculosis, diabetes mellitus and hypertension admissions and premature mortality among adults in Uganda from 2011 to 2019: is the tide turning?Tropical medicine and health · 2022Article
- Intramuscular depot medroxyprogesterone acetate accentuates bone loss associated with tenofovir disoproxil fumarate-containing antiretroviral therapy initiation in young women living with HIV (the BONE: CARE study): a prospective cohort study in Uganda.The Lancet. Global health · 2022Article
- HIV combination prevention and declining orphanhood among adolescents, Rakai, Uganda, 2001-18: an observational community cohort study.The lancet. HIV · 2022Observational
- Health and demographic surveillance systems in low- and middle-income countries: history, state of the art and future prospects.Global health action · 2021Review
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Authors and funding
18 authors at 6 institutions in 4 countries.
Funding
Abstract
There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000-14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5 years for all women and from 28.6 to 33.8 years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3 years among women and 0.4 years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.
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