Evidence map›Paper›PMID 31117844›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2019

Synthesis and biological evaluation of 3-(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer's disease agents.

Yu-Heng Hu, Jie Yang, Yun Zhang, Ke-Chun Liu, Teng Liu, Jie Sun, Xiao-Jing Wang

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
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  9. An overview of structure-based activity outcomes of pyran derivatives against Alzheimer's disease.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  10. Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives.Journal of enzyme inhibition and medicinal chemistry · 2022
    Review
  11. Research progress of coumarins and their derivatives in the treatment of diabetes.Journal of enzyme inhibition and medicinal chemistry · 2022
    Review
  12. Article
  13. Review
  14. Frontiers in molecular neuroscience · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Heng Hua School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , PR China.
Jie Yanga School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , PR China.
Yun Zhange Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , PR China.
Ke-Chun Liue Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , PR China.
Teng Liua School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , PR China.
Jie Suna School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , PR China.ORCID http://orcid.org/0000-0003-0552-9061
Xiao-Jing Wanga School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The work is focused on the design of drugs that prevent and treat Alzheimer's disease (AD) and its complications. A series of 3-(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated

Indexed as

AcetylcholinesteraseAluminum ChlorideAlzheimer DiseaseAnimalsBehavior, AnimalButyrylcholinesteraseCholinesterase InhibitorsCoumarinsDose-Response Relationship, DrugDrug DesignHumansMolecular StructureStructure-Activity RelationshipZebrafishAcetylcholinesteraseAluminum ChlorideButyrylcholinesteraseCholinesterase InhibitorsCoumarins3–(4-aminophenyl)-coumarinacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesterasezebrafish

Identifiers

PMID31117844
PMCPMC6534212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.