Evidence map›Paper›PMID 31117376›Full record

ArticleACS nano2019

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders.

Milad Riazifar, M Rezaa Mohammadi, Egest J Pone, Ashish Yeri, Cecilia Lässer, Aude I Segaliny, Laura L McIntyre, Ganesh Vilas Shelke, Elizabeth Hutchins, Ashley Hamamoto and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 324 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
324citing papers in PubMed, 8 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

324 citing papers in PubMed, 8 syntheses or guidelines pooled it, 542 citations in OpenAlex.

  1. Pooled it
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  9. Review
  10. Stem Cell-Based Therapies for Central Nervous System Demyelinating Diseases: Clinical Evidence, Therapeutic Niches, and Translational Boundaries.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  11. Article
  12. Article
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  17. TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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264 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Milad RiazifarDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
M Rezaa MohammadiDepartment of Materials Science and Engineering , University of California, Irvine , Irvine , California 92697 , United States.ORCID 0000-0002-9370-3228
Egest J PoneDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Ashish YeriNeurogenomics Division , Translational Genomics Research Institute , Phoenix , Arizona 85004 , United States.
Cecilia LässerKrefting Research Center, Institute of Medicine, The Sahlgrenska Academy , University of Gothenburg , Gothenburg 40530 , Sweden.
Aude I SegalinyDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.ORCID 0000-0001-9670-8350
Laura L McIntyreDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center , University of California, Irvine , Irvine , California 92697 , United States.
Ganesh Vilas ShelkeKrefting Research Center, Institute of Medicine, The Sahlgrenska Academy , University of Gothenburg , Gothenburg 40530 , Sweden.
Elizabeth HutchinsNeurogenomics Division , Translational Genomics Research Institute , Phoenix , Arizona 85004 , United States.
Ashley HamamotoDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Erika N CalleDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Rossella CrescitelliKrefting Research Center, Institute of Medicine, The Sahlgrenska Academy , University of Gothenburg , Gothenburg 40530 , Sweden.
Wenbin LiaoDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Victor PhamDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Yanan YinDepartment of Biochemistry and Molecular Cell Biology , Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China.
Jayapriya JayaramanDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.
Jonathan R T LakeyDepartment of Surgery , University of California, Irvine , Orange , California 92868 , United States.
Craig M WalshDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center , University of California, Irvine , Irvine , California 92697 , United States.
Kendall Van Keuren-JensenNeurogenomics Division , Translational Genomics Research Institute , Phoenix , Arizona 85004 , United States.
Jan LotvallKrefting Research Center, Institute of Medicine, The Sahlgrenska Academy , University of Gothenburg , Gothenburg 40530 , Sweden.
Weian ZhaoDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Life Sciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, and Department of Biological Chemistry , University of California, Irvine , Irvine , California 92697 , United States.ORCID 0000-0002-7794-9914
University of California, Irvine · USTranslational Genomics Research Institute · USUniversity of Gothenburg · SESahlgrenska University Hospital · SEShanghai Jiao Tong University · CN

Funding

Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Mechano-sensing stem cells to study, detect and treat cancer metastasesDP2CA195763 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZHAO, WEIAN · 2014 to 2014
$2.3M
NCI NIH HHS DP2 CA195763NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed the effect of exosomes secreted from human mesenchymal stem cells (MSCs) in treating multiple sclerosis using an experimental autoimmune encephalomyelitis (EAE) mouse model. We found that intravenous administration of exosomes produced by MSCs stimulated by IFNγ (IFNγ-Exo) (i) reduced the mean clinical score of EAE mice compared to PBS control, (ii) reduced demyelination, (iii) decreased neuroinflammation, and (iv) upregulated the number of CD4+CD25+FOXP3+ regulatory T cells (Tregs) within the spinal cords of EAE mice. Co-culture of IFNγ-Exo with activated peripheral blood mononuclear cells (PBMCs) cells in vitro reduced PBMC proliferation and levels of pro-inflammatory Th1 and Th17 cytokines including IL-6, IL-12p70, IL-17AF, and IL-22 yet increased levels of immunosuppressive cytokine indoleamine 2,3-dioxygenase. IFNγ-Exo could also induce Tregs in vitro in a murine splenocyte culture, likely mediated by a third-party accessory cell type. Further, IFNγ-Exo characterization by deep RNA sequencing suggested that IFNγ-Exo contains anti-inflammatory RNAs, where their inactivation partially hindered the exosomes potential to induce Tregs. Furthermore, we found that IFNγ-Exo harbors multiple anti-inflammatory and neuroprotective proteins. These results not only shed light on stem cell therapeutic mechanisms but also provide evidence that MSC-derived exosomes can potentially serve as cell-free therapies in creating a tolerogenic immune response to treat autoimmune and central nervous system disorders.

Indexed as

AnimalsCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalExosomesFemaleHumansInterferon-gammaInterleukinsMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLMonocytesT-Lymphocytes, RegulatoryInterferon-gammaInterleukinsdrug deliveryexosomesextracellular vesiclesmesenchymal stem cellsmultiple sclerosisnanotherapeuticsregulatory T cells

Identifiers

PMID31117376
PMCPMC6880946
OpenAlexW2944971749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.