Evidence map›Paper›PMID 31117273›Full record

ArticleInternational journal of molecular sciences2019

Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome.

Tiziana Squillaro, Nicola Alessio, Stefania Capasso, Giovanni Di Bernardo, Mariarosa Anna Beatrice Melone, Gianfranco Peluso, Umberto Galderisi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  12. Methyl-CpG Binding Protein 2 in Alzheimer Dementia.International neurourology journal · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tiziana SquillaroDepartment of Advanced Medical and Surgical Sciences, Center for Rare Diseases and Inter University Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", via Sergio Pansini, 5, 80131 Naples, Italy. tiziana.squillaro@unicampania.it.
Nicola AlessioDepartment of Experimental Medicine, Campania University "Luigi Vanvitelli", via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy. nicola.alessio@unicampania.it.ORCID 0000-0002-5019-2130
Stefania CapassoDepartment of Experimental Medicine, Campania University "Luigi Vanvitelli", via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy. stefania.capasso@unicampania.it.
Giovanni Di BernardoDepartment of Experimental Medicine, Campania University "Luigi Vanvitelli", via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy. gianni.dibernardo@unicampania.it.
Mariarosa Anna Beatrice MeloneDepartment of Advanced Medical and Surgical Sciences, Center for Rare Diseases and Inter University Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", via Sergio Pansini, 5, 80131 Naples, Italy. marina.melone@unicampania.it.ORCID 0000-0002-7213-9277
Gianfranco PelusoUSA Research Institute on Terrestrial Ecosystems, National Research Council, via Pietro Castellino, 111, 80131 Naples, Italy. gianfranco.peluso@cnr.it.
Umberto GalderisiDepartment of Experimental Medicine, Campania University "Luigi Vanvitelli", via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy. umberto.galderisi@unicampania.it.
University of Campania "Luigi Vanvitelli" · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromatin modifiers play a crucial role in maintaining cell identity through modulation of gene expression patterns. Their deregulation can have profound effects on cell fate and functions. Among epigenetic regulators, the MECP2 protein is particularly attractive. Mutations in the

Indexed as

Cellular SenescenceMutationAnimalsDisease Models, AnimalDNA RepairFemaleMesenchymal Stem CellsMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMice, TransgenicMitochondriaRett SyndromeMethyl-CpG-Binding Protein 2ATP levelsautophagyDNA repairmesenchymal stromal cellsmetabolismmitochondrial ATPproteasomeRett syndromesenescence

Identifiers

PMID31117273
PMCPMC6567034
OpenAlexW2945280440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.