ArticleMedicina (Kaunas, Lithuania)2019
Peptide Mapping, In Silico and In Vivo Analysis of Allergenic Sorghum Profilin Peptides.
Article in Medicina (Kaunas, Lithuania), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0 citing papers in PubMed, 8 citations in OpenAlex.
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5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesNearly 20-30% of the world's population suffers from allergic rhinitis, among them 15% are progressing to asthma conditions. MATERIALS AND
methodsTo map the antigenic determinants responsible for IgE binding, the present study is focused on in silico modeling, simulation of Sorb PF and docking of the Sorb PF peptides (PF1-6) against IgG and IgE, followed by in vivo evaluation of the peptides for its allergenicity in mice.
resultsPeptide PF3 and PF4 displayed high docking G-scores (-9.05) against IgE only. The mice sensitized with PF3 peptide showed increased levels of IL5, IL12, TNF-alpha, and GMCSF when compared to other peptides and controls, signifying a strong, Th2-based response. Concurrently, the Th1 pathway was inhibited by low levels of cytokine IL2, IFN-γ, and IL-10 justifying the role of PF3 in allergenic IgE response.
conclusionsBased on the results of overlapping peptides PF3 and PF4, the N-terminal part of the PF3 peptide (TGQALVI) plays a crucial role in allergenic response of Sorghum profilin.
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