Evidence map›Paper›PMID 31117198›Full record

ArticleInternational journal of molecular sciences2019

Development of a Bioluminescent BRCA1-Deficient Xenograft Model of Disseminated, High-Grade Serous Ovarian Cancer.

Yen Ting Shen, Lucy Wang, James C Evans, Christine Allen, Micheline Piquette-Miller

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yen Ting ShenDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. russell.shen@mail.utoronto.ca.
Lucy WangDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. lucille.wang@mail.utoronto.ca.
James C EvansDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. james.evans@utoronto.ca.
Christine AllenDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. cj.allen@utoronto.ca.ORCID 0000-0002-4916-3965
Micheline Piquette-MillerDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. m.piquette.miller@utoronto.ca.
University of Toronto · CA

Funding

U.S. Department of Defense W81XWH-16-1-0388
6 · The paper itself

Abstract

Successful translation of preclinical data relies on valid and comprehensive animal models. While high-grade serous ovarian cancer (HGSOC) is the most prevalent subtype, the most commonly used ovarian cancer cell lines are not representative of HGSOC. In addition, 50% of ovarian cancer patients present with dysfunctional

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticModels, BiologicalAnimalsAntineoplastic AgentsBRCA1 ProteinCarboplatinCell Line, TumorCystadenocarcinoma, SerousDown-RegulationEpigenetic RepressionFemaleHumansMiceMice, Inbred NODMice, SCIDAntineoplastic AgentsBRCA1 ProteinBRCA1 protein, humanCarboplatinascitesbioluminescent imagingBRCA-deficiencycarboplatinhigh-grade serousintraperitonealmetastasisovarian cancerxenograft

Identifiers

PMID31117198
PMCPMC6566953
OpenAlexW2946633658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.