ReviewNutrients2019
Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- A Randomized Trial of Parenteral Nutrition Using a Mixed Lipid Emulsion Containing Fish Oil in Infants of Extremely Low Birth Weight: Neurodevelopmental Outcome at 12 and 24 Months Corrected Age, A Secondary Outcome Analysis.The Journal of pediatrics · 2020Trial
- Choline and Its Companions: Inter-Related Roles of Choline and B Vitamins in Fetal Development and Offspring Health.Nutrients · 2026Review
- DHA: Nutritional Programming During the First 1000 Days of Life.Nutrients · 2026Review
- A to Z of Health: An Evidence-Based Narrative Review of Multivitamin-Multimineral and Nutraceutical Supplementation.Cureus · 2026Review
- Eggs and Associated Nutrients: Implications for Brain Development and Function From Conception to Early Adulthood: A Narrative Review.Nutrition bulletin · 2026Review
- Fatty acid profiles in blood and tissues of parenteral nutrition-fed neonatal piglets using a novel lipid emulsion containing choline.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Maternal dietary patterns, breastfeeding duration, and their association with child cognitive function and head circumference growth: A prospective mother-child cohort study.PLoS medicine · 2025Article
- Maternal Plasma Choline Levels Are Positively Correlated with Maternal and Placental Phospholipid-DHA Content in Females with Obesity Who Receive DHA Supplementation.The Journal of nutrition · 2025Article
- Protective Effects of 7S,15R-Dihydroxy-16S,17S-Epoxy-Docosapentaenoic Acid (diHEP-DPA) against Blue Light-Induced Retinal Damages in A2E-Laden ARPE-19 Cells.Antioxidants (Basel, Switzerland) · 2024Article
- A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids.Nature communications · 2024Article
- External Disruption of Ocular DevelopmentThe Yale journal of biology and medicine · 2024Review
- Comparison of the nutrient composition of eggs produced in the Guatemalan highlands during the wet and dry seasons.Food science & nutrition · 2023Article
- Article
- Review
- Microbial production of docosahexaenoic acid (DHA): biosynthetic pathways, physical parameter optimization, and health benefits.Archives of microbiology · 2023Review
- Association ofNutrients · 2023Article
- Associations of maternal inflammatory states with human milk composition in mothers of preterm infants.Frontiers in nutrition · 2023Article
- Choline supplements: An update.Frontiers in endocrinology · 2023Review
- Exploring potential strategies to enhance memory and cognition in aging mice.F1000Research · 2023Article
- Tracking a Major Egg Allergen to Assess Commercial Food Label Compliance: Towards a Simple and Fast Immunosensing Device.Biosensors · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this review is to highlight current insights into the roles of choline and docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on dietary recommendations, gaps in dietary intake, and synergistic implications of both nutrients in infant brain and eye development. Adequate choline and DHA intakes are not being met by the vast majority of US adults, and even more so by women of child-bearing age. Choline and DHA play a significant role in infant brain and eye development, with inadequate intakes leading to visual and neurocognitive deficits. Emerging findings illustrate synergistic interactions between choline and DHA, indicating that insufficient intakes of one or both could have lifelong deleterious impacts on both maternal and infant health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.