Evidence map›Paper›PMID 31117179›Full record

ArticleNutrients2019

Dietary Egg Sphingomyelin Prevents Aortic Root Plaque Accumulation in Apolipoprotein-E Knockout Mice.

Courtney L Millar, Gregory H Norris, Addison Vitols, Chelsea Garcia, Samantha Seibel, Liya Anto, Christopher N Blesso

Abstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Courtney L MillarDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. courtney.millar@uconn.edu.
Gregory H NorrisDepartment of Medicine, University of Illinois, Chicago, IL 60612, USA. gnorris@uic.edu.
Addison VitolsDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. addison.vitols@uconn.edu.
Chelsea GarciaDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. chelsea.garcia@uconn.edu.
Samantha SeibelDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. samantha.seibel@uconn.edu.
Liya AntoDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. liya.anto@uconn.edu.
Christopher N BlessoDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. christopher.blesso@uconn.edu.ORCID 0000-0002-4434-4839

Funding

American Egg Board 170787
6 · The paper itself

Abstract

Western-style diets have been linked with dyslipidemia and inflammation, two well-known risk factors associated with cardiovascular disease (CVD). Dietary sphingomyelin (SM) has been reported to modulate gut microbiota, and lower serum lipids and inflammation in mice on Western-style diets. However, few studies have examined if nutritionally-relevant intake of dietary SM can impact atherosclerosis progression. Thus, the aim of this study was to determine if incorporating 0.1% (w/w) egg SM (ESM) (equivalent to ~750 mg/day in humans) into a high-fat (45% kcal), cholesterol-enriched diet (HFD) could prevent atheroprogression in apoE

Indexed as

AnimalsAortaAtherosclerosisCD36 AntigensDietEggsEpididymisGastrointestinal MicrobiomeMaleMiceMice, Knockout, ApoESphingomyelinsCD36 AntigensSphingomyelinsatherosclerosiscardiovasculardiversityeggsinflammationmicrobiotaphospholipidssphingolipids

Identifiers

PMID31117179
PMCPMC6566691

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.