ArticleInvestigative ophthalmology & visual science2019
Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Social Support and Self-Acceptance in Patients With Diabetic Retinopathy: The Mediating Role of Psychological Capital in a Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Vision-Focused Nomogram for Assessing the Risk of Depression in Diabetic Retinopathy: Integrating Visual Function, Metabolic Factors and Psychosocial Status.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Article
- Tear lactate improves the evaluation of proliferative diabetic retinopathy in type-2 diabetes patients.Molecular biomedicine · 2025Article
- Healthy Sleep Behaviors Reduce the Risk of Microvascular and Cardiovascular Complications in Patients With Type 2 Diabetes and Are Associated With Potential Serum Biomarkers: A UK Biobank Observational Cohort Study.Journal of diabetes · 2025Observational
- Impact of self-rated health status on sleep disturbance among elderly diabetics: finding from the indonesian family life survey.Sleep & breathing = Schlaf & Atmung · 2025Article
- Bidirectional link between mood disorders and diabetic retinopathy.World journal of psychiatry · 2025Article
- Association of hemoglobin with decreased prevalence of diabetic retinopathy among Tibetan male patients.Scientific reports · 2025Article
- Association of Age-Related Eye Diseases with Comorbidity of Coronary Heart Disease and Depression in a Population-Based Cohort Study.Psychology research and behavior management · 2025Article
- Introduction and reflections on the comparative physiology of sleep and circadian rhythms.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Causal effects of diabetic retinopathy on depression, anxiety and bipolar disorder in the European population: a Mendelian randomization study.Journal of endocrinological investigation · 2024Article
- Review
- Sleep quality and its associated factors among patients with type 2 diabetes mellitus in Hunan, China: a cross-sectional study.BMJ open · 2024Article
- Observational
- Association of Poor Quality of Sleep with Vision-Threatening Diabetic Retinopathy: A Matched Case-Control Study.Ophthalmology and therapy · 2023Article
- Evaluation of an Artificial Intelligence System for the Detection of Diabetic Retinopathy in Chinese Community Healthcare Centers.Frontiers in medicine · 2022Article
- Prevalence and associated factors of depression and anxiety among Chinese diabetic retinopathy patients: A cross-sectional study.PloS one · 2022Article
- Investigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose.Bioengineered · 2021Article
- Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Sleep, circadian rhythms and health.Interface focus · 2020Review
Corrections and comments
- Erratum issuedErratum2019
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Purpose: Diabetic retinopathy (DR) is associated with retinal neuronal and vascular damage. DR has previously been shown to affect the photosensitive retinal ganglion cells (pRGCs). PRGCs are essential for the entrainment of circadian rhythms; thus, DR progression could lead to worsening sleep quality and mood. We investigate the relationship between increasing DR severity, and its impact on sleep quality and mood. Methods: A total of 430 participants with DR, and 303 healthy controls with no ocular disease or preexisting sleep disorders were recruited. DR severity was grouped as follows: 1, mild nonproliferative (NPDR); 2, moderate/severe NPDR; and 3, proliferative diabetic retinopathy (PDR). Sleep, mood, and quality of life were assessed using the Pittsburgh Sleep Quality Index (PSQI), quality of life (SF-36), and Hospital Anxiety and Depression Score (HADS) questionnaires. Data were analyzed by severity of DR, and correlated with sleep, QOL, and mood and compared to controls. Results: No significant difference between PSQI scores in the DR group or the control group was identified despite severity of DR. Mean anxiety and depression scores were within the normal range for both groups. Despite a lower general health and physical function, the DR group had lower anxiety scores than controls. Conclusions: These data show that even in severe DR, sleep quality is similar to controls. However, this could be explained by the majority of individuals in this study having good visual acuities in the better eye with a residual population of pRGCs remaining unaffected by DR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.