ArticlePhysics in medicine and biology2019
The microdosimetric extension in TOPAS: development and comparison with published data.
Article in Physics in medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A standardized measurement-based approach to estimate modelled relative biological effectiveness for auditing carbon ion beams.Physics and imaging in radiation oncology · 2026Article
- Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations.Medical physics · 2026Article
- One scale to rule them all: interpretable multi-scale Deep Learning for predicting cell survival after proton and carbon ion irradiation.Frontiers in artificial intelligence · 2026Article
- Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector.Medical physics · 2025Article
- Quantifying Sensitivity of Carbon RBE Models to Reference Parameter Variations.Radiation research · 2025Article
- Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response.Medical physics · 2025Article
- TOPAS-imaging: extensions to the TOPAS simulation toolkit for medical imaging systems.Physics in medicine and biology · 2023Article
- Pre- and post-treatment image-based dosimetry inPhysics in medicine and biology · 2021Article
- Article
- The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2020Article
- Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility.Journal of applied clinical medical physics · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Microdosimetric energy depositions have been suggested as a key variable for the modeling of the relative biological effectiveness (RBE) in proton and ion radiation therapy. However, microdosimetry has been underutilized in radiation therapy. Recent advances in detector technology allow the design of new mico- and nano-dosimeters. At the same time Monte Carlo (MC) simulations have become more widely used in radiation therapy. In order to address the growing interest in the field, a microdosimetric extension was developed in TOPAS. The extension provides users with the functionality to simulate microdosimetric spectra as well as the contribution of secondary particles to the spectra, calculate microdosimetric parameters, and determine RBE with a biological weighting function approach or with the microdosimetric kinetic (MK) model. Simulations were conducted with the extension and the results were compared with published experimental data and other simulation results for three types of microdosimeters, a spherical tissue equivalent proportional counter (TEPC), a cylindrical TEPC and a solid state microdosimeter. The corresponding microdosimetric spectra obtained with TOPAS from the plateau region to the distal tail of the Bragg curve generally show good agreement with the published data.
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