Evidence map›Paper›PMID 31116976›Full record

ArticleCell reports2019

Mitohormesis Primes Tumor Invasion and Metastasis.

Timothy C Kenny, Amanda J Craig, Augusto Villanueva, Doris Germain

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  7. Article
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  10. Article
  11. Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Mitohormesis.Cell metabolism · 2023
    Review
  18. Article
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Timothy C KennyTisch Cancer Institute, Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Amanda J CraigTisch Cancer Institute, Department of Medicine, Division of Liver Diseases, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Augusto VillanuevaTisch Cancer Institute, Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Department of Medicine, Division of Liver Diseases, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Doris GermainTisch Cancer Institute, Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: doris.germain@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4M
TRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6M
Understanding the role of mitochondrial UPR-activating mtDNA landscapes in health and longevity.R01AG059635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GERMAIN, DORIS A · 2018 to 2022
$2.2M
Role of SOD1 in cancerR01CA172046 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GERMAIN, DORIS A · 2014 to 2018
$1.9M
Multiphoton Laser Scanning MicroscopeS10RR026639 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDRICH, VICTOR LOUIS · 2010 to 2010
$500k
The role of the SIRT3 axis of the mitochondrial UPR in breast cancer metastasisF31CA228259 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNY, TIMOTHY COLE · 2018 to 2020
$92k
NCI NIH HHS F31 CA228259NCI NIH HHS P30 CA196521NCI NIH HHS R01 CA172046NCI NIH HHS T32 CA078207NCRR NIH HHS S10 RR026639NIA NIH HHS R01 AG059635
6 · The paper itself

Abstract

Moderate mitochondrial stress can lead to persistent activation of cytoprotective mechanisms - a phenomenon termed mitohormesis. Here, we show that mitohormesis primes a subpopulation of cancer cells to basally upregulate mitochondrial stress responses, such as the mitochondrial unfolded protein response (UPR

Indexed as

AnimalsBreast NeoplasmsFemaleHumansMiceMitochondrial ProteinsNeoplasm MetastasisReactive Oxygen SpeciesUnfolded Protein ResponseMitochondrial ProteinsReactive Oxygen Speciesbreast cancerHSP60metastasismitochondriamitohormesisreactive oxygen speciesSIRT3SOD2unfolded protein responseUPR(mt)

Identifiers

PMID31116976
PMCPMC6579120
OpenAlexW2945251312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.