Evidence map›Paper›PMID 31116578›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

The Huxley crossbridge model as the basic mechanism for airway smooth muscle contraction.

Ling Luo, Lu Wang, Peter D Paré, Chun Y Seow, Pasquale Chitano

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Airway smooth muscle function in asthma.Frontiers in physiology · 2022
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Ling LuoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Lu WangDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Peter D ParéDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Chun Y SeowDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Pasquale ChitanoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

The cyclic interaction between myosin crossbridges and actin filaments underlies smooth muscle contraction. Phosphorylation of the 20-kDa myosin light chain (MLC20) is a crucial step in activating the crossbridge cycle. Our current understanding of smooth muscle contraction is based on observed correlations among MLC20 phosphorylation, maximal shortening velocity (

Indexed as

Actin CytoskeletonAnimalsMuscle ContractionMuscle, SkeletalMuscle, Smooth, VascularMyosin Light ChainsPhosphorylationRespiratory SystemSheepMyosin Light Chainscontraction mechanismforce-velocity propertiesinternal loadpower output

Identifiers

PMID31116578
PMCPMC6734385
OpenAlexW2944903220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.