Evidence map›Paper›PMID 31116453›Full record

ArticleScandinavian journal of medicine & science in sports2019

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Catherine L Boereboom, James E M Blackwell, John P Williams, Bethan E Phillips, Jonathan N Lund

Registry-linked trialAbstract read
In one paragraph

Article in Scandinavian journal of medicine & science in sports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04679233 (Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy), which is not on this map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  7. Feasibility and safety of an exercise-based prehabilitation intervention before cancer surgery: a pilot randomised controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  19. Preoperative physical exercise strategies for patients undergoing major abdominal cancer surgery: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Catherine L BoereboomMRC-ARUK Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, University of Nottingham, Derby, UK.ORCID https://orcid.org/0000-0003-3678-2123
James E M BlackwellMRC-ARUK Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, University of Nottingham, Derby, UK.
John P WilliamsMRC-ARUK Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, University of Nottingham, Derby, UK.
Bethan E PhillipsMRC-ARUK Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, University of Nottingham, Derby, UK.
Jonathan N LundMRC-ARUK Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, University of Nottingham, Derby, UK.

Funding

Arthritis Research UK 19891Dunhill Medical Trust R468/0216Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Versus Arthritis 19891
6 · The paper itself

Abstract

backgroundPre-operative cardiorespiratory fitness (CRF) in colorectal cancer (CRC) patients has been shown to affect post-operative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIIT) for improving fitness in pre-operative CRC patients within the 31-day cancer waiting-time targets imposed in the UK.

methodsEighteen CRC patients (13 males, mean age: 67 years (range: 52-77 years) participated in supervised HIIT on cycle ergometers 3 or 4 times each week prior to surgery. Exercise intensity during 5 × 1-minute HIIT intervals (interspersed with 90-second recovery) was 100%-120% maximum wattage achieved at a baseline cardiopulmonary exercise test (CPET). CPET before and after HIIT was used to assess CRF.

resultsPatients completed a mean of eight HIIT sessions (range 6-14) over 19 days (SD 7). There was no significant increase in VO

conclusionsOur pragmatic HIIT exercise protocol did not improve the pre-operative fitness of CRC patients within the 31-day window available in the UK to meet cancer surgical waiting-time targets.

Indexed as

Cardiorespiratory FitnessHigh-Intensity Interval TrainingPreoperative CareAgedAnaerobic ThresholdColorectal NeoplasmsExercise TestFeasibility StudiesFemaleHeart RateHumansMaleMiddle AgedOxygen ConsumptionProspective StudiesTime Factorscolorectal neoplasmsexercisepre-operative therapysurgery

Identifiers

PMID31116453
PMCPMC6771883

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.