Evidence map›Paper›PMID 31116423›Full record

ReviewCA: a cancer journal for clinicians2019

The current state of molecular testing in the treatment of patients with solid tumors, 2019.

Wafik S El-Deiry, Richard M Goldberg, Heinz-Josef Lenz, Anthony F Shields, Geoffrey T Gibney, Antoinette R Tan, Jubilee Brown, Burton Eisenberg, Elisabeth I Heath, Surasak Phuphanich and 3 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in CA: a cancer journal for clinicians, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 143 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05254132 unknown statusnot on this mapstarted 2022, after this paper: background citation

Artificial Intelligence to Help Non-Small Cell Lung Cancer Patients: Measure Lung Cancer Biology and Treatment Response Via Imaging

TypeobservationalSponsorOncoRadiomicsRan2022 to 2025Enrolled1,000ConditionsNon Small Cell Lung CancerArmsLiquid biopsy
NCT05372081 completednot on this mapstarted 2022, after this paper: background citation

Clinical and Molecular Study With Digital Support of Patients With Inoperable Lung Cancer

TypeobservationalSponsorHellenic Cooperative Oncology GroupRan2022 to 2025Enrolled200ConditionsNon-Small Cell Carcinoma of Lung, TNM Stage 4ArmsDigital platform
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Evaluation of the Effects of Nicardipine on Entrectinib Metabolism in vitro and in Rats.European journal of drug metabolism and pharmacokinetics · 2026
    Article
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  11. Review
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wafik S El-DeiryAssociate Dean for Oncologic Sciences, Warren Alpert Medical School; Director, Joint Program in Cancer Biology, Brown University and the Lifespan Cancer Institute; Professor of Pathology & Laboratory Medicine and Professor of Medical Science, Brown University, Providence, RI.
Richard M GoldbergProfessor of Medicine and Director, West Virginia University Cancer Institute, Morgantown, WV.
Heinz-Josef LenzProfessor of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.
Anthony F ShieldsProfessor of Oncology, Karmanos Cancer Institute, Detroit, MI.
Geoffrey T GibneyAssociate Professor of Medicine, Co-Leader of the Melanoma Disease Group, Lombardi Comprehensive Cancer Institute, MedStar Georgetown Cancer Institute, Washington, DC.
Antoinette R TanCo-Director of Phase I Program, Department of Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC.
Jubilee BrownProfessor and Associate Director of Gynecologic Oncology, Levine Cancer Institute, Atrium Health, Charlotte, NC.
Burton EisenbergProfessor of Clinical Surgery, University of Southern California, Los Angeles, CA.
Elisabeth I HeathProfessor of Oncology and Medicine, Karmanos Cancer Institute, Detroit, MI.
Surasak PhuphanichProfessor of Neurology, Director, Division of Neuro-Oncology, Barrow Neurological Institute, Phoenix, AZ.
Edward KimChair, Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC.
Andrew J BrennerAssociate Professor of Medicine, Mays Cancer Center at , University of Texas Health San Antonio Cancer Center, San Antonio, TX.
John L MarshallProfessor of Medicine and Oncology, Director, Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Institute, MedStar Georgetown Cancer Institute, Washington, DC.ORCID 0000-0002-3449-2344

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

The world of molecular profiling has undergone revolutionary changes over the last few years as knowledge, technology, and even standard clinical practice have evolved. Broad molecular profiling is now nearly essential for all patients with metastatic solid tumors. New agents have been approved based on molecular testing instead of tumor site of origin. Molecular profiling methodologies have likewise changed such that tests that were performed on patients a few years ago are no longer complete and possibly inaccurate today. As with all rapid change, medical providers can quickly fall behind or struggle to find up-to-date sources to ensure he or she provides optimum care. In this review, the authors provide the current state of the art for molecular profiling/precision medicine, practice standards, and a view into the future ahead.

Indexed as

Genetic TechniquesPrecision MedicineBiomarkersHumansMolecular Targeted TherapyMutationNeoplasmsBiomarkersbiomarkerscancerdrug targetgene expression profilingmolecular profilingmolecular-targeted therapymutationprecision medicinesequence analysis

Identifiers

PMID31116423
PMCPMC6767457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.