ArticleJournal of the American Geriatrics Society2019
Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Physiological factors affecting the mechanical performance of peripheral muscles: A perspective for long COVID patients through a systematic literature review.Frontiers in physiology · 2022Pooled it
- Short- and Long-Term Effect of Multidomain Lifestyle Intervention on Frailty: Post Hoc Analysis of an RCT.Journal of the American Geriatrics Society · 2025Trial
- Association of trunk and lower limb muscle thickness with sedentary behavior in patients with chronic post-stroke hemiplegia.Journal of physical therapy science · 2026Article
- Inorganic phosphate: a link between processed food and exercise intolerance in the modern world.Clinical science (London, England : 1979) · 2026Review
- Muscle oxidative capacity does not appear to influence NIRS-VOT outcomes in healthy adults.European journal of applied physiology · 2026Article
- Longitudinal association of intensity-specific physical activity and sedentary behavior with dynapenia among older Taiwanese adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults.GeroScience · 2024Article
- Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA).Journal of sport and health science · 2024Article
- Metabolic dysfunction and the development of physical frailty: an aging war of attrition.GeroScience · 2024Review
- Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Exploring the links of skeletal muscle mitochondrial oxidative capacity, physical functionality, and mental well-being of cancer survivors.Scientific reports · 2024Article
- Postcontraction [acetylcarnitine] reflects interindividual variation in skeletal muscle ATP production patterns in vivo.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Risk and Protective Factors for Frailty in Pre-Frail and Frail Older Adults.International journal of environmental research and public health · 2023Article
- Correlates of physical activity levels, muscle strength, working memory, and cognitive function in older adults.Frontiers in aging neuroscience · 2023Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Assessment of Physical Activity in Adults Using Wrist Accelerometers.Epidemiologic reviews · 2022Review
- The Usefulness of Radiomics Methodology for Developing Descriptive and Prognostic Image-Based Phenotyping in the Aging Population: Results From a Small Feasibility Study.Frontiers in aging · 2022Article
- Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing.The Journal of physiology · 2021Article
- Association of Mitochondrial Function, Substrate Utilization, and Anaerobic Metabolism With Age-Related Perceived Fatigability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Cardiovascular Health and Mitochondrial Function: Testing an Association.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAge-related decline in muscle oxidative capacity reduces muscle function and physical performance, leading to disability and frailty. Whether age-related decline in oxidative capacity is modified by exercise and other lifestyle practices is unclear. Therefore, we tested the hypothesis that physical activity is associated with better oxidative capacity, independent of age.
designCross-sectional study performed in the Baltimore Longitudinal Study of Aging, conducted by the Intramural Research Program (IRP) of the National Institute on Aging (NIA).
settingNIA IRP Clinical Research Unit, Baltimore, MD.
participantsParticipants included 384 adults (54.7% women), aged 22 to 92 years, seen between 2013 and 2017. MEASUREMENTS: Muscle oxidative capacity was measured in vivo using phosphorous magnetic resonance spectroscopy. We determined the postexercise time constant (τ
resultsIn linear regression models, higher τ
conclusionStudy findings suggest that MVPA is strongly associated with muscle oxidative capacity, independent of age, providing mechanistic insights into the health benefits of exercise in older age. J Am Geriatr Soc 67:1695-1699, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.