ArticleInternational journal of cancer2020
A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women.
Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Dairy Consumption and Total Cancer and Cancer-Specific Mortality: A Meta-Analysis of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Pooled it
- The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Differential effects of low or high-fat dairy and fat derived from dairy products on MASLD.JHEP reports : innovation in hepatology · 2024Article
- Contemporary epidemiology of hepatocellular carcinoma: understanding risk factors and surveillance strategies.Journal of the Canadian Association of Gastroenterology · 2024Review
- Prediagnostic plasma proteomics profile for hepatocellular carcinoma.Journal of the National Cancer Institute · 2024Article
- Diet, lifestyle factors, comorbidities, and hepatocellular carcinoma risk in a middle eastern country: a case-control study.BMC cancer · 2024Article
- Dairy consumption and liver cancer risk: A meta‑analysis of observational studies.Oncology letters · 2024Article
- Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma.World journal of gastroenterology · 2023Review
- Review
- CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.Immunologic research · 2022Article
- Lifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations.Cancers · 2021Review
- Dietary N-Nitroso Compounds and Risk of Hepatocellular Carcinoma: A USA-Based Study.Hepatology (Baltimore, Md.) · 2021Article
- Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality.Nature communications · 2021Article
- Non-alcoholic fatty liver disease: A patient guideline.JHEP reports : innovation in hepatology · 2021Article
- Food Environments and Hepatocellular Carcinoma Incidence.International journal of environmental research and public health · 2021Article
- Dairy consumption and hepatocellular carcinoma risk.Annals of translational medicine · 2021Review
- Lifetime Impact of Cow's Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration.Biomolecules · 2021Review
- Role of lncRNA NR2F1-AS1 and lncRNA H19 Genes in Hepatocellular Carcinoma and Their Effects on Biological Function of Huh-7.Cancer management and research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Although increasing dairy product intake has been associated with risk of several cancers, epidemiological studies on hepatocellular carcinoma are sparse and have yielded inconsistent results. We prospectively assessed the associations of dairy products (total, milk, butter, cheese and yogurt) and their major components (calcium, vitamin D, fats and protein) with the risk of hepatocellular carcinoma development among 51,418 men and 93,427 women in the Health Professionals Follow-Up Study and the Nurses' Health Study. Diets were collected at baseline and updated every 4 years using validated food frequency questionnaires. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression model. During up to 32 years of follow-up, a total of 164 hepatocellular carcinoma cases were documented. After adjustment for most known hepatocellular carcinoma risk factors, higher total dairy product intake was associated with an increased risk of hepatocellular carcinoma (highest vs. lowest tertile, HR = 1.85, 95% CI: 1.19-2.88; p
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.