Evidence map›Paper›PMID 31116314›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2019

The ERBB2 gene polymorphisms rs2643194, rs2934971, and rs1058808 are associated with increased risk of gastric cancer.

K C Vázquez-Ibarra, A R Bustos-Carpinteyro, A García-Ruvalcaba, M T Magaãa-Torres, R Gutiérrez-Aguilar, M E Marín-Contreras, E Santiago-Luna, J Y Sánchez-López

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In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

K C Vázquez-IbarraDivision of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-1871-2693
A R Bustos-CarpinteyroDivision of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0003-2219-2253
A García-RuvalcabaDivision of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-0210-3156
M T Magaãa-TorresDivision of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-9843-0644
R Gutiérrez-AguilarDepartment of Gastroenterology, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0001-7959-1066
M E Marín-ContrerasDepartment of Gastroenterology, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-8352-236X
E Santiago-LunaDepartment of Gastroenterology, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-6946-2305
J Y Sánchez-LópezDivision of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.ORCID http://orcid.org/0000-0002-0876-6225
Mexican Social Security Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is the third most lethal type of cancer worldwide. Single nucleotide polymorphisms (SNPs) in regulatory sites or coding regions can modify the expression of genes involved in gastric carcinogenesis, as ERBB2, which encodes for the tyrosine-kinase receptor HER-2. The aim of this work was to analyze the association of the polymorphisms: rs2643194, rs2517951, rs2643195, rs2934971, and rs1058808 with GC, as they have not yet been analyzed in GC patients, as well as to report their frequency in the general Mexican population (GMP). We studied genomic DNA from subjects with GC (n=74), gastric inflammatory diseases (GID, n=76 control subjects), and GMP (n=102). Genotypes were obtained by means of real-time PCR and DNA-sequencing. The risks for GC were estimated through odds ratio (OR) using the Cochran-Armitage trend test and multinomial logistic regression. Increased risk for GC was observed under the dominant inheritance model for the rs2643194 TT or CT genotypes with an OR of 2.75 (95%CI 1.12-6.75, P=0.023); the rs2934971 TT or GT genotypes with an OR of 2.41 (95%CI 1.01-5.76, P=0.043), and the rs1058808 GG or CG genotypes with an OR of 2.21 (95%CI 1.00-4.87, P=0.046). The SNPs rs2643194, rs2934971, and rs1058808 of the ERBB2 gene were associated with increased risk for GC.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overCase-Control StudiesErb-b2 Receptor Tyrosine KinasesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideStomach NeoplasmsYoung AdultERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID31116314
PMCPMC6526748
OpenAlexW2945177337

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.