ArticleJournal of applied oral science : revista FOB2019
The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion.
Article in Journal of applied oral science : revista FOB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Biomimetic Strategies for Subsurface Enamel Remineralization: Depth-Dependent Effects of Biomimetic Agents Compared with Fluoride.Biomimetics (Basel, Switzerland) · 2026Article
- AnInternational journal of clinical pediatric dentistry · 2026Article
- Assessment of Remineralization Treatment on Primary Enamel's Microhardness and Mineral Composition Post Iron Drop Interaction.International journal of dentistry · 2026Article
- Time-Effect Comparative Evaluation of Three Remineralizing Agents on Artificial Enamel Lesions: A SEM-EDX In Vitro Study.Journal of clinical medicine · 2025Article
- Effect of yttrium/lanthanum-doped ultrasonically assisted nano-hydroxyapatite on remineralization and bracket bond strength in artificial enamel lesions.BMC oral health · 2025Article
- Evaluation of the effectiveness of different remineralization agents on primary and permanent teeth exposed to acidic liquids: a randomized controlled in vitro study.BMC oral health · 2025Article
- The Role of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in White Spot Lesion Remineralization-A Systematic Review.Journal of functional biomaterials · 2025Review
- Efficacy of Remineralizing Agents for Prevention of Microhardness Reduction and Change in Mineral Content of Enamel in Anterior Primary Teeth after Exposure to Iron Drop.Journal of dentistry (Shiraz, Iran) · 2025Article
- Bioactive milk peptides: an updated comprehensive overview and database.Critical reviews in food science and nutrition · 2024Review
- Effect of the use of remineralization agents before resin infiltration on the treatment of initial enamel lesions: an in-vitro study.BMC oral health · 2024Article
- Biomimetic Remineralization of Artificial Caries Lesions with a Calcium Coacervate, Its Components and Self-Assembling Peptide PBioengineering (Basel, Switzerland) · 2024Article
- Comparative Evaluation of Remineralizing Potential of Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate with Fluoride: AnJournal of pharmacy & bioallied sciences · 2024Article
- Effect of cheese and casein phosphopeptide-amorphous calcium phosphate on erosive lesions of primary teeth enamel following exposure to amoxicillin and ibuprofen syrups: AnDental research journal · 2024Article
- Article
- Effect of Two Remineralizing Agents on Dentin Microhardness of Non-Caries Lesions.Journal of dentistry (Shiraz, Iran) · 2023Article
- Bioactive Materials for Caries Management: A Literature Review.Dentistry journal · 2023Review
- Evaluation of the Efficacy of CPP-ACP Remineralizing Mousse in Molar-Incisor Hypomineralized Teeth Using Polarized Raman and Scanning Electron Microscopy-AnBiomedicines · 2022Article
- On the Application of Calcium Phosphate Micro- and Nanoparticles as Food Additive.Nanomaterials (Basel, Switzerland) · 2022Review
- Remineralization of early enamel lesions with a novel prepared tricalcium silicate paste.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this in vitro study was to determine the effects of remineralization promoting agents containing casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP), or CPP-ACP in combination with fluoride (CPP-ACPF) on artificial white spot lesions (WSLs) after 6 and 12 weeks. METHODOLOGY: White spot lesions were created on 123 sectioned premolars (246 specimens) with a demineralization solution during a 96 hours pH-cycling regime. Two experimental groups were created: a CPP-ACP group (Tooth Mousse™), and a CPP-ACPF group (Mi Paste Plus™). Additionally, two control groups were created, one using only a conventional toothpaste (1450 ppm fluoride) and another one without any working agents. All teeth were also daily brushed with the conventional toothpaste except the second control group. Tooth Mousse™ and Mi Paste Plus™ were applied for 180 seconds every day. The volume of demineralization was measured with transverse microradiography. Six lesion characteristics regarding the lesion depth and mineral content of WSLs were also determined.
resultsThe application of CPP-ACP and CPP-ACPF had a significant regenerative effect on the WSLs. Compared to Control group 1 and 2 the volume of demineralization after 6 weeks decreased significantly for CPP-ACP (respectively p<0.001 and p<0.001) and CPP-ACPF (respectively p=0.001 and p=0.003). The same trend was observed after 12 weeks. For the CPP-ACPF group, WSL dimensions decreased significantly between 6 and 12 weeks follow-up (p=0.012). The lesion depth reduced significantly after application of CPP-ACP and CPP-ACPF but increased significantly in the Control groups. Mineral content increased for CPP-ACP and CPP-ACPF after an application period of 12 weeks, but this was only significant for CPP-ACP.
conclusionsLong-term use of CPP-ACP and CPP-ACPF in combination with a conventional tooth paste shows beneficial effects in the recovery of in vitro subsurface caries lesions.
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Registered trials
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