SynthesisRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review.
Synthesis in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Altered amygdala resting-state functional connectivity in anxiety disorders: a coordinate-based meta-analysis.Psychological medicine · 2026Pooled it
- Wearable Artificial Intelligence for Detecting Anxiety: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2023Pooled it
- The Relationship Between Cognitive Functioning and Symptoms of Depression, Anxiety, and Post-Traumatic Stress Disorder in Adults with a Traumatic Brain Injury: a Meta-Analysis.Neuropsychology review · 2022Pooled it
- Meta-analytical transdiagnostic neural correlates in common pediatric psychiatric disorders.Scientific reports · 2022Pooled it
- Music Therapy Modulates Abnormal Brain Networks and Alleviates Anxiety Symptoms in University Students: An fNIRS Study.Depression and anxiety · 2025Trial
- Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.Translational psychiatry · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Brain activation, sleep disturbances, and psychological distress in women undergoing assisted reproductive treatment: a functional near-infrared spectroscopy study.BMC psychology · 2026Article
- Myo-Inositol Levels in the Dorsal Anterior Cingulate Cortex Are Associated With Anxiety-to-Eat in Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Modulation of monoaminergic neurotransmission in substance use disorders: a neuropharmacological perspective focusing on plant-derived metabolites.Frontiers in pharmacology · 2026Review
- Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025Review
- Age-Related Changes in the Amygdala From In Utero to Early Childhood: Association With Social and Cognitive Outcomes.Human brain mapping · 2025Article
- Mobile Mental Health Screening in EmotiZen via the Novel Brain-Inspired MCoG-LDPSNet.Biomimetics (Basel, Switzerland) · 2025Article
- Article
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder.Depression and anxiety · 2025Article
- Aberrant resting-state functional connectivity in medication-naïve generalized anxiety disorder: a whole-brain exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Interplay among Anxiety, Digital Environmental Exposure, and Cognitive Control: Implications of Natural Settings.Behavioral sciences (Basel, Switzerland) · 2024Article
- Research status and trends of physical activity on depression or anxiety: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBrain imaging studies carried out in patients suffering from generalized anxiety disorder (GAD) have contributed to better characterize the pathophysiological mechanisms underlying this disorder. The present study reviews the available functional and structural brain imaging evidence on GAD, and suggests further strategies for investigations in this field.
methodsA systematic literature review was performed in PubMed, PsycINFO, and Google Scholar, aiming to identify original research evaluating GAD patients with the use of structural and functional magnetic resonance imaging as well as diffusion tensor imaging.
resultsThe available studies have shown impairments in ventrolateral and dorsolateral prefrontal cortex, anterior cingulate, posterior parietal regions, and amygdala in both pediatric and adult GAD patients, mostly in the right hemisphere. However, the literature is often tentative, given that most studies have employed small samples and included patients with comorbidities or in current use of various medications. Finally, different methodological aspects, such as the type of imaging equipment used, also complicate the generalizability of the findings.
conclusionsLongitudinal neuroimaging studies with larger samples of both juvenile and adult GAD patients, as well as at risk individuals and unaffected relatives, should be carried out in order to shed light on the specific biological signature of GAD.
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