Trial reportOptometry and vision science : official publication of the American Academy of Optometry2019
Impact of Dry Eye on Visual Acuity and Contrast Sensitivity: Dry Eye Assessment and Management Study.
Trial report in Optometry and vision science : official publication of the American Academy of Optometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05713981 (The Impact of Dry Eye Syndrome on Novel Metrics of Low Contrast Vision Before and After Therapeutic Meibomian Gland Expression), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Dry Eye Syndrome on Novel Metrics of Low Contrast Vision Before and After Therapeutic Meibomian Gland Expression
Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Dry Eye Disease: From Mechanisms to Management and Future Directions.Journal of clinical medicine · 2026Review
- Patients' knowledge, attitudes, and practices toward dry eye disease management.BMC ophthalmology · 2025Article
- Article
- Article
- Investigation of the influencing factors on subjective evaluation in initial and end-of-day silicone hydrogel contact lens wear.BMC ophthalmology · 2025Article
- Impact of cyclosporine A on the progression of ocular surface diseases: treatment efficacy and potential complications.Journal of medical microbiology · 2025Article
- The Duration of Cataract Surgery and the Change in Postoperative Dry Eye Disease Parameters: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- Effects of regular spectacle wear on binocular accommodative function in myopic adults with dry eye disease.Frontiers in medicine · 2025Article
- Dry Eye Treatment with Intense Pulsed Light for Improving Visual Outcomes After Cataract Surgery with Diffractive Trifocal Intraocular Lens Implantation.Journal of clinical medicine · 2024Article
- The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- The Influence of Tear Film Quality on Visual Function.Vision (Basel, Switzerland) · 2024Article
- Predisposing factors for poor outcomes after intense pulsed light treatment for dry eye disease: A retrospective case-control study.International journal of medical sciences · 2024Article
- Impact of TearCare on Reading Speed in Patients with Dry Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Digital Challenges: Investigating Computer Vision Syndrome in Thai Esports Through a Case-Control Approach.Clinical optometry · 2024Article
- Dry eye rate and its relationship with disease stage in patients with primary hypertension: a cross-sectional study in Vietnam.International journal of ophthalmology · 2024Article
- Animal Models in Eye Research: Focus on Corneal Pathologies.International journal of molecular sciences · 2023Review
- Association between Corneal Higher-Order Aberrations Evaluated with a Videokeratographer and Corneal Surface Abnormalities in Dry Eye.Diagnostics (Basel, Switzerland) · 2023Article
- Cyclodialysis Cleft and Hypotony Following Combined Phacoemulsification and Excisional Goniotomy with the Kahook Dual Blade.Turkish journal of ophthalmology · 2023Article
- Visual resolution under photopic and mesopic conditions in patients with Sjögren's syndrome.International journal of ophthalmology · 2023Article
- Dry eye disease in astronauts: a narrative review.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
significanceIdentification of the association of specific signs of dry eye disease with specific visual function deficits may allow for more targeted approaches to treatment. PURPOSE: The purpose of this study was to explore the association of dry eye signs and symptoms with visual acuity (VA) and contrast sensitivity in the Dry Eye Assessment and Management study.
methodsBaseline data from participants in the Dry Eye Assessment and Management study were used in this secondary cross-sectional analysis. Standardized procedures were used to obtain results on the Ocular Surface Disease Index (OSDI), high-contrast logMAR VA, contrast sensitivity, tear film debris, tear breakup time (TBUT), corneal fluorescein staining, meibomian gland evaluation, conjunctival lissamine green staining, and Schirmer test scores. Generalized linear models that included age, refractive error status, and cataract status were used to assess the association between VA and contrast sensitivity with OSDI score and each dry eye sign. The Hochberg procedure was used to account for multiple comparisons.
resultsAmong 487 participants (974 eyes), worse VA was associated with worse mean score on the OSDI vision subscale (39.4 for VA 20/32 or worse vs. 32.4 for VA 20/16 or better; adjusted linear trend, P = .02); scores were not associated with contrast sensitivity. Severe meibomian gland plugging and abnormal secretions were associated with worse mean log contrast sensitivity (1.48 for severe vs. 1.54 for not plugged [P = .04] and 1.49 for obstructed vs. 1.57 for clear [P = .002], respectively). Longer TBUT was associated with better mean log contrast sensitivity (1.57 for TBUT >5 seconds and 1.51 for TBUT ≤2 seconds, P < .0001).
conclusionsWorse VA rather than worse contrast sensitivity drives vision-related symptoms in dry eye. Greater tear film instability was associated with worse contrast sensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.