Evidence map›Paper›PMID 31116007›Full record

ArticleObesity (Silver Spring, Md.)2019

Variants in BMI-Associated Genes and Adrenergic Genes are not Associated with Gestational Weight Trajectory.

Vivian K Kawai, Samuel K Nwosu, Daniel Kurnik, Frank E Harrell, C Michael Stein

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vivian K KawaiDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5841-2575
Samuel K NwosuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Daniel KurnikDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Frank E HarrellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
C Michael SteinDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
Automated Storage and Retrieval of Biological SystemsS10RR025141 · NCRR · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2008 to 2008
$988k
Pharmacogenetic Determinants of Variability in Response to GlucocorticoidsK23GM117395 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KAWAI, VIVIAN K · 2015 to 2018
$736k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS S10 RR025141NHLBI NIH HHS P01 HL056693NIGMS NIH HHS K23 GM117395
6 · The paper itself

Abstract

objectiveThe aim of this study is to define the association between a genetic risk score (GRS) that combined the effect of multiple BMI-associated variants and gestational weight trajectory. Because pregnancy is a state of sympathetic activation, the association between gestational weight trajectory and variants in adrenergic pathways previously associated with weight was examined.

methodsIn a previously defined cohort of pregnant women with (n = 1,504) and without gestational diabetes (GDM) (n = 435), weight trajectory was calculated using all weights during pregnancy. A GRS for BMI (GRS

resultsPrepregnancy BMI was associated with the GRS

conclusionsA GRS for BMI was associated with prepregnancy BMI but was not independently associated with gestational weight trajectory in women with and without GDM. Selected variants in adrenergic genes were not associated with gestational weight trajectory.

Indexed as

Body Mass IndexBody-Weight TrajectoryAdultFemaleGenotypeHumansPregnancyRisk Factors

Identifiers

PMID31116007
PMCPMC6591076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.