Evidence map›Paper›PMID 31115843›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

Cancer-related symptoms, mental well-being, and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy.

Sarah Wilding, Amy Downing, Penny Wright, Peter Selby, Eila Watson, Richard Wagland, David W Donnelly, Luke Hounsome, Hugh Butcher, Malcolm Mason and 3 more

Abstract read
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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Exploring the role of psychological flexibility in relationship functioning among couples coping with prostate cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Patient activation and patient-reported outcomes of men from a community pharmacy lifestyle intervention after prostate cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  12. Strategies for living well with hormone-responsive advanced prostate cancer-a qualitative exploration.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sarah WildingLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. S.E.Wilding@leeds.ac.uk.ORCID http://orcid.org/0000-0002-7977-7132
Amy DowningLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Penny WrightLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Peter SelbyLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Eila WatsonDepartment of Midwifery, Community and Public Health, School of Nursing and Midwifery, Oxford Brookes University, Oxford, UK.
Richard WaglandFaculty of Health Sciences, University of Southampton, Southampton, UK.
David W DonnellyNorthern Ireland Cancer Registry, Queen's University Belfast, Belfast, UK.
Luke HounsomeNational Cancer Registration and Analysis Service, Public Health England, Bristol, UK.
Hugh ButcherLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Malcolm MasonDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.
Ann HenryLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Anna GavinNorthern Ireland Cancer Registry, Queen's University Belfast, Belfast, UK.
Adam W GlaserLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

Funding

Movember Foundation BO26/MOProstate Cancer UK BO26/MO
6 · The paper itself

Abstract

purposeThere are known associations between treatment of prostate cancer (PCa) involving Androgen Deprivation Therapy (ADT) and psychological and physical side effects. We investigate the associations between cancer-related symptoms, health-related quality of life (HRQL), and poor psychological outcomes in men whose treatment for PCa involved ADT.

methodsA cross-sectional postal questionnaire was administered to UK men 18-42 months post diagnosis of PCa. Men completed items on functional outcomes using the Expanded Prostate Cancer Index Composite (EPIC-26), EuroQol-5D (EQ-5D), and the European Organisation for Research and Treatment of Cancer (EORTC) Fatigue subscale. Psychological outcomes (mental well-being and psychological distress) were assessed using the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) and the Kessler 6-item scale (K6), respectively. Associations between explanatory variables and psychological outcomes were assessed using stepped logistic regression.

results13,097 men treated with ADT completed a questionnaire. A minority of men reported poor mental well-being (15.5%) or severe psychological distress (6.6%). After controlling for sociodemographic and clinical variables, reporting clinically significant fatigue was strongly associated with severe psychological distress (OR 9.92; 95% CI 7.63 to 12.89) and poor well-being (OR 3.86; 95% CI 3.38 to 4.42). All cancer-related symptoms and HRQL variables were associated with both psychological outcomes.

conclusionsWhile the majority of men treated with ADT did not report poor psychological outcomes, a small proportion reported severe problems. Clinically significant fatigue was demonstrated as a possible indicator of poor outcomes. Healthcare systems need to have clear protocols in place which specifically and routinely target psychological distress and fatigue.

Indexed as

AgedAndrogen AntagonistsCross-Sectional StudiesHumansMaleMental HealthProstatic NeoplasmsQuality of LifeStress, PsychologicalSurveys and QuestionnairesAndrogen AntagonistsAndrogen deprivation therapyCancer-related symptomsMental well-beingPatient-reported outcome measuresProstate cancerPsychological distress

Identifiers

PMID31115843
PMCPMC6761086

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.