Evidence map›Paper›PMID 31115781›Full record

ArticleClinical journal of gastroenterology2019

A novel pathogenic variant of ATP-binding cassette subfamily B member 4 causing gallstones in a young adult.

Tetsuya Ishizawa, Naohiko Makino, Yasuharu Kakizaki, Yoshiaki Ando, Akiko Matsuda, Toshikazu Kobayashi, Chisaki Ikeda, Shinpei Sugahara, Michihiko Tsunoda, Hidenori Sato and 2 more

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In one paragraph

Article in Clinical journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tetsuya IshizawaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan. ishizawa1028@med-id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0001-5137-3868
Naohiko MakinoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Yasuharu KakizakiDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Yoshiaki AndoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Akiko MatsudaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Toshikazu KobayashiDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Chisaki IkedaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Shinpei SugaharaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Michihiko TsunodaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Hidenori SatoGenome Informatics Unit, Institute for Promotion of Medical Science Research, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Ryoko MurakamiGenome Informatics Unit, Institute for Promotion of Medical Science Research, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Yoshiyuki UenoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata-shi, Yamagata, 990-8595, Japan.
Yamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The low phospholipid-associated cholelithiasis (LPAC) syndrome was reported in European adults with cholelithiasis and a mutation of the ATP-binding cassette subfamily B member 4 (ABCB4). The ABCB4 encodes multidrug resistance 3, which is a phospholipid translocator. Reduced phospholipid transport can lead to the formation of biliary cholesterol stones. Here, we describe a 31-year-old Japanese man diagnosed with recurrent biliary colic. Although he recovered quickly after endoscopic treatment for the most recent presentation, he had a family history of similar problems. His mother had required endoscopic treatment for choledocholithiasis and his maternal aunt had died at age 29 years because of liver failure (etiology unknown). We, therefore, performed genetic analysis, which revealed a heterozygous ABCB4

Indexed as

AdultATP-Binding Cassette TransportersBiliary Tract DiseasesCholagogues and CholereticsColicGallstonesHeterozygoteHumansMaleMutationPhospholipidsRecurrenceSyndromeUrsodeoxycholic AcidABCA4 protein, humanATP-Binding Cassette TransportersCholagogues and CholereticsPhospholipidsUrsodeoxycholic AcidABCB4LPACMDR3

Identifiers

PMID31115781
OpenAlexW2944906859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.