ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019
Emergence of metal selectivity and promiscuity in metalloenzymes.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Unsymmetric bimetallic centres in metalloproteins and synthetic models.Nature reviews. Chemistry · 2026Review
- Photocontrolled Release of Urea Enables the Detection of Urea-Urease Intermediates by Cryo-FTIR.Angewandte Chemie (International ed. in English) · 2025Article
- Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation.Journal of the American Chemical Society · 2025Article
- Enantioconvergent benzylic C(spScience (New York, N.Y.) · 2025Article
- A De Novo Designed Metalloprotein Displays Variable Thermal Stability and Binding Stoichiometry with Transition Metal Ions.Chembiochem : a European journal of chemical biology · 2025Article
- Reaction Mechanism and Metal Selectivity of Human SAMHD1 Elucidated by QM/MM Calculations.ACS catalysis · 2025Article
- Recent advances and future challenges in predictive modeling of metalloproteins by artificial intelligence.Molecules and cells · 2025Review
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections.Biochimica et biophysica acta. Molecular cell research · 2024Review
- Unveiling the role of inorganic nanoparticles in Earth's biochemical evolution through electron transfer dynamics.iScience · 2024Review
- An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive.FEMS microbiology reviews · 2024Review
- Metal ion stimulation-related gene signatures correlate with clinical and immunologic characteristics of glioma.Heliyon · 2024Article
- M-Ionic: prediction of metal-ion-binding sites from sequence using residue embeddings.Bioinformatics (Oxford, England) · 2024Article
- The role of transcriptional regulators in metal ion homeostasis ofFrontiers in cellular and infection microbiology · 2024Review
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Two related families of metal transferases, ZNG1 and ZNG2, are involved in acclimation to poor Zn nutrition in Arabidopsis.Frontiers in plant science · 2023Article
- A systematicFrontiers in plant science · 2023Article
- A Combined Experimental and Theoretical Investigation of Oxidation Catalysis byInorganic chemistry · 2022Article
- Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving-Williams Behavior.Journal of the American Chemical Society · 2022Article
- The quintessence of metallomics: a harbinger of a different life science based on the periodic table of the bioelements.Metallomics : integrated biometal science · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Metal coordination with proteinaceous ligands has greatly expanded the chemical toolbox of proteins and their biological roles. The structure and function of natural metalloproteins have been determined according to the physicochemical properties of metal ions bound to the active sites. Concurrently, amino acid sequences are optimized for metal coordination geometry and/or dedicated action of metal ions in proteinaceous environments. In some occasions, however, natural enzymes exhibit promiscuous reactivity with more than one designated metal ion, under in vitro and/or in vivo conditions. In this review, we discuss selected examples of metalloenzymes that bind various first-row, mid- to late-transition metal ions for their native catalytic activities. From these examples, we suggest that environmental, inorganic, and biochemical factors, such as bioavailability, native organism, cellular compartment, reaction mechanism, binding affinity, protein sequence, and structure, might be responsible for determining metal selectivity or promiscuity. The current work proposes how natural metalloproteins might have emerged and adapted for specific metal incorporation under the given circumstances and may provide insights into the design and engineering of de novo metalloproteins.
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