ArticleFish physiology and biochemistry2019
RNA-seq and microRNA-seq analysis of Japanese flounder (Paralichthys olivaceus) larvae treated by thyroid hormones.
Article in Fish physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Differential Methylation Analysis of Hypermelanosis in Chinese Tongue Sole (Cynoglossus semilaevis).Marine biotechnology (New York, N.Y.) · 2025Article
- Transcriptome analysis of the Japanese eel (Anguilla japonica) during larval metamorphosis.BMC genomics · 2024Article
- Identification of Potential Blind-Side Hypermelanosis-Related lncRNA-miRNA-mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Frontiers in genetics · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Flatfish pigmentation is a complex process, affected by environmental factors including light, nutrients, and hormones. Of those, the thyroid hormone has been reported to increase the albinism rate of Japanese flounder (Paralichthys olivaceus). However, the underlying mechanism remains unclear. In the present study, triiodothyronine (T3), thyroxine, and thiourea were introduced into P. olivaceus larvae from 16 to 57 days after hatching (DAH). By comparison of albinism rate, T3 treatment and control larvae of 42 DAH were chosen for mRNA and miRNA high-throughput sequencing analyses. A total of 337 miRNAs were identified via miRNA-seq, and 12 miRNAs exhibited significantly differential expression patterns in D42_T3 versus D42_Con (TPM > 10, fold change ≥ 1.5 or ≤ 0.67 and q ≤ 0.05). These differentially expressed miRNAs targeted 3658 putative genes, which further enriched to 10 GO terms (q < 0.05). RNA-seq identified 146 differentially expressed genes (DEGs) in D42_T3 versus D42_Con (|log
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Registered trials
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