Evidence map›Paper›PMID 31115739›Full record

Trial reportSleep & breathing = Schlaf & Atmung2020

The effects of threshold inspiratory muscle training in patients with obstructive sleep apnea: a randomized experimental study.

Huei-Chen Lin, Ling-Ling Chiang, Jun-Hui Ong, Kun-Ling Tsai, Ching-Hsia Hung, Cheng-Yu Lin

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05210998 (Investigation of the Effects of Respiratory Muscle Training Combined With Aerobic Exercise in Persons With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05210998 nacompletednot on this mapstarted 2022, after this paper: background citation

Investigation of the Effects of Respiratory Muscle Training Combined With Aerobic Exercise in Persons With Obstructive Sleep Apnea Syndrome

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2022 to 2023Enrolled36ConditionsObstructive Sleep Apnea SyndromeArmsGradual Aerobic exercise training AND Respiratory muscle training, Gradual Aerobic exercise training
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Inspiratory muscle training as adjuvant therapy in obstructive sleep apnea: a randomized controlled trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Trial
  5. Article
  6. Exploring Exercise Interventions for Obstructive Sleep Apnea: A Scoping Review.Journal of functional morphology and kinesiology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
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  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Huei-Chen LinInstitute of Allied Health Sciences, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan.
Ling-Ling ChiangSchool of Respiratory Therapy, Taipei Medical University, No. 250 Wuxing St., Taipei, 11031, Taiwan.
Jun-Hui OngDepartment of Physical Therapy, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan.
Kun-Ling TsaiDepartment of Physical Therapy, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan.
Ching-Hsia HungInstitute of Allied Health Sciences, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan.
Cheng-Yu LinDepartment of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd., North Dist., Tainan City, 70403, Taiwan. yu621109@ms48.hinet.net.

Funding

Gary & Amy Foundation no numberShu-Zen Junior College of Medicine and Management SZPT10403008
6 · The paper itself

Abstract

objectivesPatients with obstructive sleep apnea (OSA) (an obstructed airway and intermittent hypoxia) negatively affect their respiratory muscles. We evaluated the effects of a 12-week threshold inspiratory muscle training (TIMT) program on OSA severity, daytime sleepiness, and pulmonary function in newly diagnosed OSA.

methodsSixteen patients with moderate-to-severe OSA were randomly assigned to a TIMT group and 6 to a control group. The home-based TIMT program was 30-45 min/day, 5 days/week, for 12 weeks using a TIMT training device. Their apnea-hypopnea index (AHI), Epworth sleepiness scale (ESS), and forced vital capacity (FVC) scores were evaluated pre- and post-treatment. Polysomnographic (PSG) analysis showed that 9 TIMT-group patients had positively responded (TIMT-responder group: post-treatment AHI < pre-treatment) and that 7 had not (TIMT non-responder group: post-treatment AHI > pre-treatment).

resultsPost-treatment AHI and ESS scores were significantly (both P < 0.05) lower 6% and 20.2%, respectively. A baseline AHI ≤ 29.0/h predicted TIMT-responder group patients (sensitivity 77.8%; specificity 85.7%). FVC was also significantly (P < 0.05) higher 7.2%. Baseline AHI and FEV

conclusionsHome-based TIMT training is simple, efficacious, and cost-effective.

Indexed as

Breathing ExercisesDisorders of Excessive SomnolenceFollow-Up StudiesHumansInhalationPolysomnographySleep Apnea, ObstructiveTreatment OutcomeVital CapacityApnea-hypopnea indexForced vital capacityObstructive sleep apneaThreshold inspiratory muscle training

Identifiers

PMID31115739

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.