Evidence map›Paper›PMID 31115711›Full record

ArticleEJNMMI research2019

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans.

Kevin S Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers and 8 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  8. Article
  9. New Long-Acting [Journal of medicinal chemistry · 2023
    Article
  10. Article
  11. Molecular therapy. Nucleic acids · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Kevin S ThorneloeGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Armin SeppGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
Sean ZhangGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Laura Galinanes-GarciaGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
Paul GaletteGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Wasfi Al-AzzamGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Danielle J VugtsVU University Medical Center, 1081 HV, Amsterdam, The Netherlands.
Guus van DongenVU University Medical Center, 1081 HV, Amsterdam, The Netherlands.
Phillip ElsingaUniversity of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands.
Johan WiegersUniversity of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands.
Andor W J M GlaudemansUniversity of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands.
Veena VincentGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Jessica RenauxGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
Matt SzapacsGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Mary BirchlerGSK, South Collegeville Road, Collegeville, PA, 19426, USA.
Matthew ClevelandGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
Mats BergstromGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
Marie DaviesGSK, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK. marie.l.davies@gsk.com.ORCID http://orcid.org/0000-0002-0821-4236
South College · USAge UK · GBUniversity Medical Center Groningen · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand extravasation kinetics and extravascular organ concentrations of AlbudAbs in humans, we studied tissue distribution and elimination of a non-conjugated

methodsA non-conjugated AlbudAb (GSK3128349) was radiolabeled with

results

conclusionEvaluating the biodistribution of

Indexed as

89ZrAlbudAbAlbuminBiodistributionDomain antibodyPET/CT

Identifiers

PMID31115711
PMCPMC6529487
OpenAlexW2946986122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.