ArticleClinical oral investigations2020
Effect of a novel quaternary ammonium silane cavity disinfectant on cariogenic biofilm formation.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Interrogation of imaging-based interspecies dynamics in the oral microbiome.Journal of oral microbiology · 2026Review
- Chemomechanical Caries Removal with Enzymatic Technology: A ComparativeInternational journal of clinical pediatric dentistry · 2025Article
- Omics for deciphering oral microecology.International journal of oral science · 2024Review
- Shifting from Ammonium to Phosphonium Salts: A Promising Strategy to Develop Next-Generation Weapons against Biofilms.Pharmaceutics · 2024Review
- Microparticles as BDMDAC (Quaternary Ammonium Compound) Carriers for Water Disinfection: A Layer-by-Layer Approach without Biocide Release.Nanomaterials (Basel, Switzerland) · 2023Article
- Article
- In-vitro evaluation of the effectiveness of polyphenols based strawberry extracts for dental bleaching.Scientific reports · 2023Article
- Biochemical changes and macrophage polarization of a silane-based endodontic irrigant in an animal model.Scientific reports · 2022Article
- Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance.Microorganisms · 2022Review
- Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry.Frontiers in microbiology · 2022Review
- Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Quaternary ammonium silane (k21) based intracanal medicament triggers biofilm destruction.BMC oral health · 2021Article
- Effect of Propolis Nanoparticles againstMolecules (Basel, Switzerland) · 2021Article
- Enhanced Spontaneous Antibacterial Activity of δ-MnOFrontiers in bioengineering and biotechnology · 2021Article
- Mapping of a Subgingival Dual-Species Biofilm Model Using Confocal Raman Microscopy.Frontiers in microbiology · 2021Article
- Effect of a novel quaternary ammonium silane based cavity cleanser FiteBac 2% K21 QAS in comparison with other cavity disinfectants on the bond strength of resin-modified glass ionomer cement.Journal of conservative dentistry and endodonticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvaluate effect of quaternary ammonium silane (QAS) cavity disinfectant on cariogenic biofilm. MATERIALS AND
methodsSingle- (Streptococcus mutans or Lactobacillus acidophilus), dual- (Streptococcus mutans/Lactobacillus Acidophilus), and multi-species (Streptococcus mutans, Actinomyces naeslundii, and Streptococcus sanguis) biofilms were grown on acid-etched dentine discs. Biofilms were incubated (120 min/37 °C) and allowed to grow for 3 days anaerobically. Discs (no treatment) served as control (group 1). Groups II, III, IV, and V were then treated with 2% chlorhexidine, and 2%, 5%, and 10% QAS (20 s). Discs were returned to well plates with 300 μL of bacterial suspension and placed in anaerobic incubator at 37 °C and biofilms redeveloped for 4 days. Confocal microscopy, Raman, CFU, and MTT assay were performed.
resultsRaman peaks show shifts at 1450 cm
conclusionQuaternary ammonium silanes possess antimicrobial activities and inhibit growth of cariogenic biofilms. CLINICAL SIGNIFICANCE: Available data demonstrated use of QAS as potential antibacterial cavity disinfectant in adhesive dentistry. Experimental QAS can effectively eliminate caries-forming bacteria, when used inside a prepared cavity, and can definitely overcome problems associated with present available cavity disinfectants.
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31115692What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.