ArticleClinical oral investigations2020
Investigating unset endodontic sealers' eugenol and hydrocortisone roles in modulating the initial steps of inflammation.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Spontaneous and Masticatory Post-endodontic Pain After Using Endomethasone N vs SP Root Canal Sealers: A Randomised Controlled Clinical Trial.European endodontic journal · 2024Trial
- Evaluation of Postoperative Pain Frequency in Single-Session Endodontic Treatments With Patency and Foraminal Enlargement.Clinical and experimental dental research · 2026Article
- Immunomodulatory Effects of Endodontic Sealers: A Systematic Review.Dentistry journal · 2023Review
- Evaluation of Apical Leakage After Root Canal Obturation with Glass Ionomer, Resin, and Zinc Oxide Eugenol Sealers Combined with Thermafil.Medical science monitor basic research · 2022Article
- Morpho-functional effects of different universal dental adhesives on human gingival fibroblasts: an in vitro study.Odontology · 2021Article
- Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown.Oxidative medicine and cellular longevity · 2021Review
- Transforaminal and systemic diffusion of an active agent from a zinc oxide eugenol-based endodontic sealer containing hydrocortisone-in an in vivo model.Clinical oral investigations · 2020Article
- Foreign body-associated maxillary sinus aspergillosis caused by Endomethasone extrusion: diagnostic challenges, biological mechanisms, and surgical management.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEndodontic treatment success is achieved not only when the cement provides a hermetic seal but also when the injured periapical tissue is regenerated. However, an exaggerated inflammatory reaction hinders tissue regeneration and it has been shown that dental materials affect the inflammatory response through modulation of cytokine secretion. This work was set to investigate the effects of the presence of hydrocortisone in zinc oxide eugenol sealers (Endomethasone N) on modulating the initial steps of inflammation in vitro. MATERIAL AND
methodsHydrocortisone and eugenol leaching from Endomethasone N and Pulp Canal Sealer (PCS) were quantified by ELISA and spectrofluorometry, respectively. The effects of Endomethasone N and Pulp Canal Sealer were studied on lipopolysaccharides (LPS)-stimulated human periodontal ligament (hPDL) cells. Cytokine (IL-6, TNF-α) secretion from cells was quantified by ELISA. Inflammatory cell (THP-1) adhesion to activated endothelial cells, their migration and activation were studied in vitro.
resultsEndomethasone N decreased secretion of IL-6 and TNF-α from hPDL cells. THP-1 adhesion to activated endothelial cells (HUVECs) and migration significantly decreased with Endomethasone N while no effect was observed with PCS. Activation of THP-1 decreased with both materials' extracts but was significantly lower with Endomethasone N than with PCS.
conclusionThese results performed in vitro show that Endomethasone N anti-inflammatory effects are due to the presence of hydrocortisone. CLINICAL RELEVANCE: Endomethasone N has potential local anti-inflammatory effects which appear to be due to its hydrocortisone rather than eugenol content. Decreasing the inflammatory response is a pre-requisite to initiate the periapical healing.
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