ArticleEuropean radiology2019
Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- Machine Learning-Based Automatic Diagnosis of Osteoporosis Using Bone Mineral Density Measurements.Journal of clinical medicine · 2026Article
- Advancing bone health evaluation in Hermann's tortoises (Frontiers in veterinary science · 2026Article
- Accuracy and Robustness of Bone Volume Fraction Assessment by Photon-Counting, Dual-Energy, and Quantitative CT using Micro-CT as Standard of Reference.Annals of biomedical engineering · 2025Article
- In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT: Prospective Comparison With DXA.Investigative radiology · 2025Article
- Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.BMC musculoskeletal disorders · 2025Article
- A three-material model for dual-layer detector spectral computed tomography measurements of marrow adipose tissue and bone mineral density.JBMR plus · 2025Article
- Comparison of bone mineral density quantification in dogs using spectral detector computed tomography versus phantom-based conventional computed tomography.Frontiers in veterinary science · 2025Article
- The q-Dixon sequence for MRI predicts osteoporotic vertebral compression fractures.Frontiers in endocrinology · 2025Article
- Dark-field radiography for the detection of bone microstructure changes in osteoporotic human lumbar spine specimens.European radiology experimental · 2024Article
- Automated deep learning-based bone mineral density assessment for opportunistic osteoporosis screening using various CT protocols with multi-vendor scanners.Scientific reports · 2024Article
- Calcium-Based Imaging of the Spine at Dual-Layer CT and Evaluation of Vertebral Fractures in Multiple Myeloma.Cancers · 2024Article
- Correlation between vertebral bone mineral density and multi-level virtual non-calcium imaging parameters from dual-layer spectral detector computed tomography.Quantitative imaging in medicine and surgery · 2024Article
- Longitudinal MR-based proton-density fat fraction (PDFF) and T2* for the assessment of associations between bone marrow changes and myelotoxic chemotherapy.European radiology · 2024Article
- Artificial Intelligence Applications for Osteoporosis Classification Using Computed Tomography.Bioengineering (Basel, Switzerland) · 2023Review
- Quantification of bone quality and distribution of the proximal humerus with dual-energy computed tomography.Quantitative imaging in medicine and surgery · 2023Article
- Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Comparison of volumetric and areal bone mineral density in CT and scout scans using spectral detector technology.European radiology experimental · 2023Article
- Automatic segmentation and radiomic texture analysis for osteoporosis screening using chest low-dose computed tomography.European radiology · 2023Article
- Opportunistic Screening Techniques for Analysis of CT Scans.Current osteoporosis reports · 2023Review
- The new fast kilovoltage-switching dual-energy computed tomography for measuring bone mineral density.Quantitative imaging in medicine and surgery · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the in vivo applicability of non-contrast-enhanced hydroxyapatite (HA)-specific bone mineral density (BMD) measurements based on dual-layer CT (DLCT).
methodsA spine phantom containing three artificial vertebral bodies with known HA densities was measured to obtain spectral data using DLCT and quantitative CT (QCT), simulating different patient positions and grades of obesity. BMD was calculated from virtual monoenergetic images at 50 and 200 keV. HA-specific BMD values of 174 vertebrae in 33 patients (66 ± 18 years; 33% women) were determined in non-contrast routine DLCT and compared with corresponding QCT-based BMD values.
resultsExamining the phantom, HA-specific BMD measurements were on a par with QCT measurements. In vivo measurements revealed strong correlations between DLCT and QCT (r = 0.987 [95% confidence interval, 0.963-1.000]; p < 0.001) and substantial agreement in a Bland-Altman plot.
conclusionDLCT-based HA-specific BMD measurements were comparable with QCT measurements in in vivo analyses. This suggests that opportunistic DLCT-based BMD measurements are an alternative to QCT, without requiring phantoms and specific protocols. KEY POINTS: • DLCT-based hydroxyapatite-specific BMD measurements show a substantial agreement with QCT-based BMD measurements in vivo. • DLCT-based hydroxyapatite-specific measurements are on a par with QCT in spine phantom measurements. • Opportunistic DLCT-based BMD measurements may be a feasible alternative for QCT, without requiring dedicated examination protocols or a phantom.
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