Evidence map›Paper›PMID 31115303›Full record

Observational studyThe American journal of tropical medicine and hygiene2019

Determination of Benznidazole in Human Dried Blood Spots by Liquid Chromatography-Mass Spectrometry to Monitor Adherence to

Jeremiah D Momper, Nathan J Hanan, Steven S Rossi, Mark H Mirochnick, Maria Luisa Cafferata, Antonia Lavenia, Isolina Flores, Luz Gibbons, Alvaro Ciganda, Sergio Sosa Estani and 2 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Jeremiah D MomperUniversity of California, San Diego, La Jolla, California.
Nathan J HananUniversity of California, San Diego, La Jolla, California.
Steven S RossiUniversity of California, San Diego, La Jolla, California.
Mark H MirochnickBoston University School of Medicine, Boston, Massachusetts.
Maria Luisa CafferataUnidad de Investigación Clínica Montevideo (UNICEM), Montevideo, Uruguay.
Antonia LaveniaMinisterio de Salud Pública de la Provincia de Tucumán, Tucumán, Argentina.
Isolina FloresMinisterio de Salud Pública de la Provincia de Tucumán, Tucumán, Argentina.
Luz GibbonsInstituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina.
Alvaro CigandaUnidad de Investigación Clínica Montevideo (UNICEM), Montevideo, Uruguay.
Sergio Sosa EstaniInstituto Nacional de Parasitología "Dr. Mario Fatala Chaben," Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Administracion Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbran" (ANLIS), Buenos Aires, Argentina.
Edmund V CapparelliUniversity of California, San Diego, La Jolla, California.
Pierre BuekensSchool of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
University of California, San Diego · USMinisterio de Salud - Provincia de Buenos Aires · ARUniversidad de Montevideo · UYBoston University · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Efectividad Clínica y Sanitaria · ARTulane University · US

Funding

Congenital Transmission of Lineages I and II of Trypanasoma cruziR01AI083563 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI BUEKENS, PIERRE · 2010 to 2014
$2.7M
Short-course Benznidazole Treatment to Reduce Trypanosoma cruzi Parasitic Load in Women of Reproductive Age: A Non-inferiorityRandomized Controlled TrialR01HD095857 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BUEKENS, PIERRE, CAFFERATA, MARÍA LUISA · 2018 to 2022
$2.6M
NIAID NIH HHS R01 AI083563NICHD NIH HHS R01 HD095857
6 · The paper itself

Abstract

Medication adherence is critical to the effectiveness of benznidazole (BZ) therapy for the treatment of Chagas disease. Assessing BZ adherence using traditional plasma sampling methods presents numerous challenges in resource-limited settings. Dried blood spot (DBS) sampling of BZ can be used to overcome logistical barriers and provides a less invasive method for assessing BZ levels. A BZ DBS assay using liquid chromatography-tandem mass spectrometry was developed and applied to a clinical study of infants and children being treated with BZ for

Indexed as

Medication AdherenceChagas DiseaseChildChild, PreschoolChromatography, LiquidDried Blood Spot TestingFemaleHumansInfantInfant, NewbornMaleMass SpectrometryNitroimidazolesProspective StudiesTrypanocidal AgentsbenzonidazoleNitroimidazolesTrypanocidal Agents

Identifiers

PMID31115303
PMCPMC6609196
OpenAlexW2946347374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.