Evidence map›Paper›PMID 31115178›Full record

ArticleAndrology2019

Semen quality of young men in Switzerland: a nationwide cross-sectional population-based study.

R Rahban, L Priskorn, A Senn, E Stettler, F Galli, J Vargas, M Van den Bergh, A Fusconi, R Garlantezec, T K Jensen and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Andrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  7. Review
  8. Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid.Metabolomics : Official journal of the Metabolomic Society · 2023
    Article
  9. Spatiotemporal trends in human semen quality.Nature reviews. Urology · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

R RahbanDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
L PriskornDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
A SennDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
E StettlerDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
F GalliNational Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland.
J VargasCentre de Procréation Médicalement Assistée SA, Fertas SA et Fondation FABER, Lausanne, Switzerland.
M Van den BerghKinderwunschzentrum, Kantonspital Baden, Baden, Switzerland.
A FusconiCentro Cantonale di Fertilità, Ospedale di Locarno La Carità, Locarno, Switzerland.
R GarlantezecInserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Université de Rennes, Rennes, France.
T K JensenDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
L MultignerInserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Université de Rennes, Rennes, France.ORCID 0000-0003-3205-8568
N E SkakkebaekDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
M GermondCentre de Procréation Médicalement Assistée SA, Fertas SA et Fondation FABER, Lausanne, Switzerland.
N JørgensenDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4827-0838
S NefDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-5462-0676
NICER Working Group
University of Copenhagen · DKUniversity of Geneva · CHInserm · FRCentre for Medically Assisted Procreation · CHKantonsspital Baden · CHLudwig Cancer Research · CHOspedale Regionale di Locarno · CHUniversidade de Santiago de Compostela · ES

Funding

FABER FoundationFondation privée des Hôpitaux Universitaires de GenèveMedical Services of Swiss Army (DDPS)MedisupportSwiss Centre for Applied Human Toxicology - SCAHTSwiss National Science Foundation NRP50
6 · The paper itself

Abstract

backgroundSperm counts have been steadily decreasing over the past five decades with regional differences in the Western world. The reasons behind these trends are complex, but numerous insights indicate that environmental and lifestyle factors are important players.

objectiveTo evaluate semen quality and male reproductive health in Switzerland. MATERIALS AND

methodsA nationwide cross-sectional study was conducted on 2523 young men coming from all regions of Switzerland, recruited during military conscription. Semen volume, sperm concentration, motility, and morphology were analyzed. Anatomy of the genital area and testicular volume was recorded. Testicular cancer incidence rates in the general population were retrieved from Swiss regional registries.

resultsMedian sperm concentration adjusted for period of sexual abstinence was 48 million/mL. Comparing with the 5th percentile of the WHO reference values for fertile men, 17% of men had sperm concentration below 15 million/mL, 25% had less than 40% motile spermatozoa, and 43% had less than 4% normal forms. Disparities in semen quality among geographic regions, urbanization rates, and linguistic areas were limited. A larger proportion of men with poor semen quality had been exposed in utero to maternal smoking. Furthermore, testicular cancer incidence rates in the Swiss general population increased significantly between 1980 and 2014. DISCUSSION: For the first time, a systematic sampling among young men has confirmed that semen quality is affected on a national level. The median sperm concentration measured is among the lowest observed in Europe. No specific geographical differences could be identified. Further studies are needed to determine to what extent the fertility of Swiss men is compromised and to evaluate the impact of environmental and lifestyle factors.

conclusionA significant proportion of Swiss young men display suboptimal semen quality with only 38% having sperm concentration, motility, and morphology values that met WHO semen reference criteria.

Indexed as

Semen AnalysisAdolescentCross-Sectional StudiesFemaleHumansLife StyleMaleMaternal ExposureOligospermiaSpermatozoaSperm CountSperm MotilitySwitzerlandYoung Adultgeographic variationslifestyle factorssemen qualitysperm counttesticular canceryoung men

Identifiers

PMID31115178
PMCPMC6790593
OpenAlexW2945446162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.