ArticleJournal of veterinary internal medicine2019
Membrane-based therapeutic plasma exchange in dogs: Prescription, anticoagulation, and metabolic response.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Regional citrate anticoagulation for replacement therapy in patients with liver failure: A systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Effects of centrifugation-based therapeutic plasma exchange on coagulation parameters in dogs with canine visceral leishmaniasis.The veterinary quarterly · 2026Article
- Case Report: Therapeutic plasma exchange for systemic centipede envenomation in a 2-kg Chihuahua dog.Frontiers in veterinary science · 2026Article
- Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.Science advances · 2025Article
- Evaluation of the safety and feasibility of extracorporeal therapy: therapeutic plasma exchange in dogs - report of five cases.BMC veterinary research · 2025Article
- Diagnostic Pathways ofPathogens (Basel, Switzerland) · 2024Article
- Acoustofluidic-based therapeutic apheresis system.Nature communications · 2024Article
- Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption.Pathogens (Basel, Switzerland) · 2024Article
- Manual therapeutic plasma exchange for treatment of a dog with suspected acute canine polyradiculoneuritis.Acta veterinaria Scandinavica · 2023Article
- Outcomes of 434 dogs with non-steroidal anti-inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange.Journal of veterinary internal medicine · 2023Article
- Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs.Journal of veterinary internal medicine · 2022Article
- Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus).Journal of veterinary internal medicine · 2021Article
- Evaluation of membrane-based therapeutic plasma exchange as adjunctive treatment for immune-mediated hematologic disorders in dogs.Journal of veterinary internal medicine · 2021Article
- Membrane-based therapeutic plasma exchange in dogs: Prescription, anticoagulation, and metabolic response.Journal of veterinary internal medicine · 2019Article
- Updated ACVIM consensus statement on leptospirosis in dogs.Journal of veterinary internal medicineArticle
- Treatment of Naproxen Overdose Using Therapeutic Plasma Exchange and Plasmaperfusion in a Dog.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTherapeutic plasma exchange (TPE) is used increasingly in small animals to remove circulating large molecular products such as antibodies, pathogenic proteins, and protein-bound toxins. Specific, efficient, and safe protocols need to be developed. HYPOTHESIS/
objectivesTo describe the technique of membrane-based TPE, the resulting physiological and metabolic changes, and to define an adequate regional citrate anticoagulation protocol. ANIMALS: Thirty-four dogs treated with TPE (2011-2017).
methodsRetrospective review of all TPE treatments performed at the Vetsuisse Faculty, University of Bern, identified through a search of the institutional database for extracorporeal treatments.
resultsSixty-four treatments were performed, resulting in 1.0 plasma volume exchange (range, 0.4-1.1). Replacement fluids included fresh frozen plasma (12%-100% volume), colloids (0%-52%), human albumin (0%-41%), and saline (0%-70%). Anticoagulation was performed with regional citrate (n = 24), systemic heparinization (n = 2), or combined (n = 38). Main relevant laboratory changes included a 24.7% decrease in total proteins (interquartile range, 16.7-31.4; P < .001), 53% in fibrinogen (-30 to 63; P = .009), 36% in bilirubin (13-43, P = .02), 9.0% in urea (0.7-15.7; P < .001), and 4.5% in creatinine (-6.6 to 10.6; P = .006). Citrate accumulation was evidenced in all dogs, more pronounced in those with renal but not with hepatic impairment. Maximal tolerable citrate rates were estimated as 5.5 and 9.0 μmol/kg/min for treatments in dogs with and without renal impairment, respectively. Complications were observed in 22 treatments (34%) and were fatal in 2 dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Therapeutic plasma exchange causes metabolic and biochemical alterations. Understanding these effects makes possible to anticipate most complications and to improve safety of the procedure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.