ArticleJournal of clinical laboratory analysis2019
Elevated circulating lnc-ANRIL/miR-125a axis level predicts higher risk, more severe disease condition, and worse prognosis of sepsis.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Recent advances in the biosensing platforms for sepsis diagnosis.RSC advances · 2026Review
- Unveiling the Role of LncRNA in Sepsis-Associated Encephalopathy.Current medical science · 2025Review
- lncRNA Biomarkers of Glioblastoma Multiforme.Biomedicines · 2024Review
- Interaction between long noncoding RNA and microRNA in lung inflammatory diseases.Immunity, inflammation and disease · 2024Review
- LncRNA CDKN2B-AS1 interacts with LIN28B to exacerbate sepsis-induced acute lung injury by inducing HIF-1α/NLRP3-mediated pyroptosis.The Kaohsiung journal of medical sciences · 2023Article
- Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases.Reviews in cardiovascular medicine · 2023Review
- Identification of autophagy-related genes and immune cell infiltration characteristics in sepsis via bioinformatic analysis.Journal of thoracic disease · 2023Article
- Non-Coding RNA Networks as Potential Novel Biomarker and Therapeutic Target for Sepsis and Sepsis-Related Multi-Organ Failure.Diagnostics (Basel, Switzerland) · 2022Review
- Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.Critical care (London, England) · 2022Review
- Modes of action and diagnostic value of miRNAs in sepsis.Frontiers in immunology · 2022Review
- Long Non-Coding RNAs ANRIL and HOTAIR Upregulation is Associated with Survival in Neonates with Sepsis in a Neonatal Intensive Care Unit.International journal of general medicine · 2022Article
- Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network.BMC pulmonary medicine · 2021Article
- Long Noncoding RNA: Regulatory Mechanisms and Therapeutic Potential in Sepsis.Frontiers in cellular and infection microbiology · 2021Review
- The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction.Frontiers in cardiovascular medicine · 2021Review
- Long Non-Coding RNAs as Biomarkers and Therapeutic Targets in Sepsis.Frontiers in immunology · 2021Review
- Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis.Frontiers in immunology · 2021Review
- Long noncoding RNA NEAT 1 and its target microRNA-125a in sepsis: Correlation with acute respiratory distress syndrome risk, biochemical indexes, disease severity, and 28-day mortality.Journal of clinical laboratory analysis · 2020Article
- Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis.Molecular therapy. Nucleic acids · 2020Review
- Long non-coding RNA MALAT1/microRNA 125a axis presents excellent value in discriminating sepsis patients and exhibits positive association with general disease severity, organ injury, inflammation level, and mortality in sepsis patients.Journal of clinical laboratory analysis · 2020Article
- Elevated circulating lnc-ANRIL/miR-125a axis level predicts higher risk, more severe disease condition, and worse prognosis of sepsis.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
aimThis study aimed to investigate the correlation of lnc-ANRIL/miR-125a axis with risk, severity, inflammation, and prognosis of sepsis.
methodsA hundred and twenty-six sepsis patients and 125 healthy controls were recruited, and then, blood samples were collected, and plasma was separated for lnc-ANRIL, miR-125a, lnc-ANRIL/miR-125a axis, and inflammatory cytokine level detections. In addition, basic characteristics, 28-day mortality, and accumulating survival of sepsis patients were recorded.
resultsPlasma lnc-ANRIL expression was increased, miR-125a expression was decreased, and lnc-ANRIL/miR-125a axis level was elevated in sepsis patients compared with healthy controls, and all of them had good value for predicting sepsis risk with AUCs of 0.800, 0.817, and 0.843, respectively. Lnc-ANRIL and lnc-ANRIL/miR-125a axis were positively correlated with biochemical index levels including CRP and PCT levels, disease severity scale scores, and pro-inflammatory cytokine levels in sepsis patients, while miR-125a displayed the opposite trend. Lnc-ANRIL and lnc-ANRIL/miR-125a axis expressions were elevated, while miR-125a expression was declined in deaths compared with survivors, and all of them predicted 28-day mortality in sepsis patients with AUCs of 0.765, 0.745, and 0.785, respectively. Subsequently, the Kaplan-Meier analysis revealed that patients with high lnc-ANRIL, low miR-125a, and high lnc-ANRIL/miR-125a axis levels presented with worse accumulating survival. In addition, multivariate regression model analyses revealed that high plasma lnc-ANRIL/miR-125a axis was an independent predictive factor for both increased 28-day mortality and worse accumulating survival.
conclusionCirculating lnc-ANRIL/miR-125a axis was upregulated and could serve as a biomarker for severity, inflammation, and prognosis in sepsis patients.
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