ArticleScience advances2019
Lysostaphin and BMP-2 co-delivery reduces
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 100 citations in OpenAlex.
- The application of growth factors in bone tissue engineering delivery systems and collaborative innovation strategies.Annals of medicine · 2026Review
- Hydrogels for Local Drug Delivery in Biofilm-Associated Periprosthetic Joint Infection: Current Progress and Future Directions.Microorganisms · 2026Review
- Eradication of MRSA biofilm-associated implant infections by low-immunogenic sustained-release lysostaphin fused to thermosensitive polypeptides.Nature communications · 2026Article
- Osteoimmunology uncovered: How macrophages and biomaterials revolutionize bone healing.Materials today. Bio · 2026Review
- Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection.Nature communications · 2026Article
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Unconventional Therapies in Periprosthetic Joint Infections: Prevention and Treatment: A Narrative Review.Journal of clinical medicine · 2025Review
- Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials.Journal of nanobiotechnology · 2025Review
- Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review.Nanomedicine (London, England) · 2025Review
- From injury to integrity: tissue engineering solutions in combined bone repair and regeneration and muscle repair.Burns & trauma · 2025Review
- A review on the promising antibacterial agents in bone cement-From past to current insights.Journal of orthopaedic surgery and research · 2024Review
- Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions.Signal transduction and targeted therapy · 2024Review
- Efficacy of lysostaphin-coated titanium plates on implant-associated MRSA osteitis in minipigs.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections.Journal of bone and joint infection · 2024Review
- Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair.Bioactive materials · 2023Article
- Poly Ethylene Glycol (PEG)-Based Hydrogels for Drug Delivery in Cancer Therapy: A Comprehensive Review.Advanced healthcare materials · 2023Review
- Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis.BMC medicine · 2023Article
- Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity.Science advances · 2023Article
- Flourishing Antibacterial Strategies for Osteomyelitis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Christopher T JohnsonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-8884-6761
Mary Caitlin P SokWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Karen E MartinPetit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0003-0261-6709
Pranav P KalelkarPetit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-7460-6537
Jeremy D CaplinPetit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-6945-8947
Edward A BotchweyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Andrés J GarcíaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-6602-2518
Georgia Institute of Technology · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3MOsseo-reparative, integrin-specific materialsR01AR062920 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2021
$3.2MBacteriophage Presenting Hydrogels to Treat OsteomyelitisF30AR069472 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI JOHNSON, CHRISTOPHER THOMAS · 2016 to 2019
$197kNIAMS NIH HHS F30 AR069472NIAMS NIH HHS R01 AR062920NIGMS NIH HHS T32 GM008169
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAnti-Bacterial AgentsBone Morphogenetic Protein 2Bone RegenerationDrug Delivery SystemsHydrogelsInflammationLysostaphinMaleMiceMice, Inbred C57BLOrthopedic ProceduresProstheses and ImplantsRecombinant ProteinsStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBone Morphogenetic Protein 2HydrogelsLysostaphinrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor beta
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.