ArticleFrontiers in cell and developmental biology2019
A Qualitative Study Exploring Barriers and Facilitators of Enrolling Underrepresented Populations in Clinical Trials and Biobanking.
Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Implementation of precision medicine in treating non-communicable diseases: a systematic review.Journal of translational medicine · 2025Pooled it
- Racial and ethnic disparities in communication study enrollment for young people with cancer: A descriptive analysis of the literature.Patient education and counseling · 2022Pooled it
- Pooled it
- Beyond mistrust: Diverse biobanking preferences among parents and adolescents with sickle cell disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Outreach to Native Hawaiian and Pacific Islander communities to increase breast cancer screening and clinical trial awareness.BMC cancer · 2026Article
- Messaging Informed by Behavioral Economics and Representativeness in Clinical Research Enrollment: Four Randomized Clinical Trials.JAMA network open · 2026Article
- Developing and validating machine learning algorithms to predict various indices of diet quality among a socio-economically disadvantaged group.The British journal of nutrition · 2026Article
- Designing communication strategies to increase rural participation in clinical trials using the Health Belief Model and strategic communication.Contemporary clinical trials communications · 2026Article
- Decentralized clinical trials in cardiovascular disease : A primer for clinical trialists.Nature cardiovascular research · 2026Review
- Article
- Strategies to build trustworthiness and increase diversity in colorectal cancer biospecimen research: a multi-phase, multi-site qualitative study.Journal of community genetics · 2026Article
- Barriers and Facilitators to Participation in the Employees' Health Cohort Study of Iran (EHCSIR): A Qualitative Content Analysis.Medical journal of the Islamic Republic of Iran · 2026Article
- A novel computational analysis integrating social determinants information from EHR and literature with Alzheimer's disease biological knowledge through large language models and knowledge graphs.Innovation in aging · 2025Article
- Potential Barriers to Participating in Cancer Moonshot Biobank for Low-Income Patients with Cancer of Rural Maine.Biopreservation and biobanking · 2025Article
- Article
- Barriers and Facilitators to Cancer Clinical Trial Participation: Perspectives of Patients in the ICON-3 Practice-Based Research Network, Nigeria.JCO global oncology · 2025Article
- Preferences for clinical trial participation among people who use drugs in rural Oregon and Appalachian Ohio.Drug and alcohol dependence · 2025Article
- A Formative Evaluation of Interventions to Enhance Clinical Trial Diversity Guided by the Socioecological Model.Cancers · 2025Article
- Research coordinators' perspectives on recruitment of minoritized people with cystic fibrosis into clinical trials.BMC pulmonary medicine · 2025Article
- Germline testing for prostate cancer: current state and opportunities for enhanced access.EBioMedicine · 2025Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Disparities exist in enrollment in clinical trials and biorepositories among adults with low socioeconomic status, racial and ethnic minority groups and individuals who live in rural areas. Diverse participation is necessary to identify the most effective treatments in different groups. The purpose of this study was to use qualitative methods to identify factors that may affect the likelihood that members of underrepresented groups choose to participate in clinical trials and/or biobanking. We conducted 14 focus groups and seven telephone interviews in urban and rural areas of Louisiana to: (1) identify barriers and facilitators to participation; and (2) elicit input in crafting clear, culturally appropriate language and recruitment strategies. Of 103 participants, 25 were safety-net healthcare providers, 18 were primary care or oncology clinic patients, and 60 were members of social and faith-based groups. Patients and community participants were English-speaking, 79% were African American, 81% were female and 24% lived in rural areas. Barriers to participation identified were lack of knowledge about clinical trials and biobanks; limited specific information and access to participation, trust and privacy concerns about clinical trials and biobanking Facilitators included: altruism, high interest in medical research particularly studies that might benefit them or their families; plain language, culturally appropriate information; convenient access to studies; and input of a trusted provider. In addition, all primary care providers were interested in having clinical trial options available for their patients but did not have time to search for available trials. Results of this study can inform the development of education materials and strategies to increase participation of underrepresented groups in clinical trial and biobanking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.