ArticleFrontiers in genetics2019
An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Importance and variability of the paternal component in sow reproductive traits.Journal of applied genetics · 2024Review
- Transgenerational epigenetic heritability for growth, body composition, and reproductive traits in Landrace pigs.Frontiers in genetics · 2024Article
- Genome-wide DNA methylation analysis reveals different methylation patterns in Chinese indigenous sheep with different type of tail.Frontiers in veterinary science · 2023Article
- Comparing the Biological Properties of Double-Stranded DNA Extracted from Human and Porcine Placenta and Salmon Sperm.Reports of biochemistry & molecular biology · 2023Article
- Identification of a 5-Methylcytosine Site (mC-7) That May InhibitVeterinary sciences · 2022Article
- DNA methylation landscapes from pig's limbic structures underline regulatory mechanisms relevant for brain plasticity.Scientific reports · 2022Article
- Aging of Vascular System Is a Complex Process: The Cornerstone Mechanisms.International journal of molecular sciences · 2022Review
- Applications of Omics Technology for Livestock Selection and Improvement.Frontiers in genetics · 2022Review
- Genome-wide DNA methylation analysis in Chinese Chenghua and Yorkshire pigs.BMC genomic data · 2021Article
- GeneDMRs: An R Package for Gene-Based Differentially Methylated Regions Analysis.Journal of computational biology : a journal of computational molecular cell biology · 2021Article
- Comparative Analyses of Sperm DNA Methylomes Among Three Commercial Pig Breeds Reveal Vital Hypomethylated Regions Associated With Spermatogenesis and Embryonic Development.Frontiers in genetics · 2021Article
- The Future of Livestock Management: A Review of Real-Time Portable Sequencing Applied to Livestock.Genes · 2020Review
- Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint.Veterinary sciences · 2020Article
- Sperm DNA Integrity and Male Fertility in Farm Animals: A Review.Frontiers in veterinary science · 2020Review
- Impacts of Epigenetic Processes on the Health and Productivity of Livestock.Frontiers in genetics · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research. Testis is the main organ for reproduction and boar taint in pigs; however, there have been no studies to-date on adult pig testis epigenome. The main objective of this study was to establish a genome-wide DNA methylation map of pig testis that would help identify candidate epigenetic biomarkers and methylated genes for complex traits such as male reproduction, fertility or boar taint. Reduced Representation Bisulfite Sequencing (RRBS) was used to study methylation levels of cytosine in nine pig testis samples. The results showed that genome-wide methylation status of nine samples overlapped greatly and their variation among pigs were low. The methylation levels of promoter, exon, intron, cytosine and guanine dinucleotide (CpG) islands and CpG island shores regions were 0.15, 0.47, 0.55, 0.39, and 0.53, respectively. Cytosines binding to CpG islands showed different methylation levels between exon and intron regions. All methylation levels of CpG islands were lower than CpG island shores in different genic features. The distribution of 12,738 differentially methylated cytosines (DMCs) within CpG islands, CpG island shores and other regions was 36.86, 21.65, and 41.49%, respectively, and was 0.33, 1.71, 5.95, and 92.01% in promoter, exon, intron and intergenic regions, respectively. Methylation levels of DMCs in promoter, exon and intron regions were significantly different between CpG islands and CpG island shores (
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