Evidence map›Paper›PMID 31114608›Full record

ArticleFrontiers in genetics2019

Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review.

Giuseppe Petruzzellis, Iside Alessi, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Andrea Ciolfi, Lucia Pedace, Antonella Cacchione, Andrea Carai, Marco Tartaglia, Angela Mastronuzzi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. A case of disseminated spinal astroblastoma harboring a MAMLD1::BEND2 fusion.Neuropathology : official journal of the Japanese Society of Neuropathology · 2024
    Article
  6. Article
  7. Article
  8. Molecular pathology as basis for timely cancer diagnosis and therapy.Virchows Archiv : an international journal of pathology · 2024
    Review
  9. Article
  10. Brain Tumor Classification by Methylation Profile.Journal of Korean medical science · 2023
    Review
  11. Radiology-Pathology and Surgical Correlation in Astroblastoma.AJNR. American journal of neuroradiology · 2023
    Article
  12. Article
  13. Diagnostics (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giuseppe PetruzzellisDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Iside AlessiDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Giovanna Stefania ColafatiNeuroradiology Unit, Department of Imaging, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Francesca Diomedi-CamasseiDepartment of Laboratories, Pathology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Andrea CiolfiGenetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lucia PedaceDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Antonella CacchioneDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Andrea CaraiNeurosurgery Unit, Department of Neuroscience and Neurorehabilitation, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Marco TartagliaGenetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Angela MastronuzziDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Evelina MieleDepartment of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Bambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astroblastoma is a rare tumor of the central nervous system (CNS) with uncertain clinical behavior. Recently, DNA methylation profiling has been shown to provide a highly robust and reproducible approach for the classification of all CNS tumors across different age groups. By using DNA methylation profiling, a subset of CNS high-grade tumors with astroblastoma-like morphology characterized by the meningioma 1 gene (

Indexed as

astroblastomabrain tumorCNS-HGNET-MN1DNA methylation profilingnext-generation sequencing

Identifiers

PMID31114608
PMCPMC6502896
OpenAlexW2942979465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.