Evidence map›Paper›PMID 31114588›Full record

ArticleFrontiers in immunology2019

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.

Daniele Corridoni, Seiji Shiraishi, Thomas Chapman, Tessa Steevels, Daniele Muraro, Marie-Laëtitia Thézénas, Gennaro Prota, Ji-Li Chen, Uzi Gileadi, Nicola Ternette and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. The roles and heterogeneity of CD8International journal of molecular medicine · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. NOD2/RIG-I ActivatingFrontiers in immunology · 2020
    Article
  15. Article
  16. Review
  17. A Conserved Requirement forFrontiers in physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Daniele CorridoniMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Seiji ShiraishiMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Thomas ChapmanMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Tessa SteevelsMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Daniele MuraroMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Marie-Laëtitia ThézénasNuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.
Gennaro ProtaMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Ji-Li ChenMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Uzi GileadiMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Nicola TernetteThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
Vincenzo CerundoloMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Alison SimmonsMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBJohn Radcliffe Hospital · GBMRC Human Immunology Unit · GB

Funding

Cancer Research UK 11331Cancer Research UK 17722Department of Health NIHR-RP-R3-12-026Medical Research Council G0501975Medical Research Council G0800158Medical Research Council G1000800Medical Research Council MC_PC_15002Medical Research Council MC_U137884181Medical Research Council MC_UU_00008/1Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/1Medical Research Council MC_UU_12010/7Medical Research Council MR/K01577X/1Medical Research Council MR/K021222/1Medical Research Council MR/M00533X/1Medical Research Council MR/S036377/1
6 · The paper itself

Abstract

NOD2 and TLR2 recognize components of bacterial cell wall peptidoglycan and direct defense against enteric pathogens. CD8

Indexed as

Cross-PrimingAntigens, BacterialCD8-Positive T-LymphocytesCrohn DiseaseDendritic CellsEndoplasmic ReticulumHistocompatibility Antigens Class IHumansNod2 Signaling Adaptor ProteinPhosphorylationProteasome Endopeptidase ComplexProtein Serine-Threonine KinasesToll-Like Receptor 2Vesicular Transport ProteinsAntigens, BacterialHistocompatibility Antigens Class INOD2 protein, humanNod2 Signaling Adaptor ProteinProteasome Endopeptidase ComplexProtein Serine-Threonine KinasesPSMF1 protein, humanSEC16A protein, humanTBK1 protein, humanTLR2 protein, humanToll-Like Receptor 2Vesicular Transport ProteinsCD8+ T cellsCrohn's diseasecross-presentationinnate immunityNOD2TLR2

Identifiers

PMID31114588
PMCPMC6503738
OpenAlexW2951719596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.