Evidence map›Paper›PMID 31114569›Full record

ArticleFrontiers in immunology2019

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.

Daniel Perez-Zsolt, Jon Cantero-Pérez, Itziar Erkizia, Susana Benet, Maria Pino, Carla Serra-Peinado, Alba Hernández-Gallego, Josep Castellví, Gustavo Tapia, Vicent Arnau-Saz and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Under the Radar: Immune Evasion, Pathogenesis and Control of HIV Infection.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Review
  11. Human CD123Journal of virus eradication · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Antigen Presenting Cell-Mediated HIV-1Medical research archives · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Daniel Perez-ZsoltIrsiCaixa AIDS Research Institute, Badalona, Spain.
Jon Cantero-PérezDepartment of Infectious Diseases, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Itziar ErkiziaIrsiCaixa AIDS Research Institute, Badalona, Spain.
Susana BenetIrsiCaixa AIDS Research Institute, Badalona, Spain.
Maria PinoIrsiCaixa AIDS Research Institute, Badalona, Spain.
Carla Serra-PeinadoDepartment of Infectious Diseases, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Alba Hernández-GallegoInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
Josep CastellvíPathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Gustavo TapiaInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
Vicent Arnau-SazDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Julio GarridoHospital Municipal de Badalona, Badalona, Spain.
Antoni TarratsDepartment of Obstetrics and Gynecology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Maria J BuzónDepartment of Infectious Diseases, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, Badalona, Spain.
Nuria Izquierdo-UserosIrsiCaixa AIDS Research Institute, Badalona, Spain.
Meritxell GenescàDepartment of Infectious Diseases, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Universitat Autònoma de Barcelona · ESVall d'Hebron Institut de Recerca · ESHospital Universitari Germans Trias i Pujol · ESIrsiCaixa · ESHospital Municipal de Badalona · ESInstitució Catalana de Recerca i Estudis Avançats · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen presenting cells from the cervical mucosa are thought to amplify incoming HIV-1 and spread infection systemically without being productively infected. Yet, the molecular mechanism at the cervical mucosa underlying this viral transmission pathway remains unknown. Here we identified a subset of HLA-DR

Indexed as

AdultAgedAged, 80 and overBiological Transport, ActiveCervix UteriDendritic CellsFemaleHEK293 CellsHIV-1HIV InfectionsHumansInterferon Type IMiddle AgedMucous MembraneSialic Acid Binding Ig-like Lectin 1Virus ReplicationInterferon Type ISialic Acid Binding Ig-like Lectin 1SIGLEC1 protein, humancervixHIV-1myeloid cellsSiglec-1trans-infection

Identifiers

PMID31114569
PMCPMC6503733
OpenAlexW2942951702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.