Evidence map›Paper›PMID 31114476›Full record

ArticleFrontiers in neuroscience2019

Mediating Retinal Ganglion Cell Spike Rates Using High-Frequency Electrical Stimulation.

Tianruo Guo, David Tsai, Chih Yu Yang, Amr Al Abed, Perry Twyford, Shelley I Fried, John W Morley, Gregg J Suaning, Socrates Dokos, Nigel H Lovell

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  8. Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022
    Article
  9. Review
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  12. Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2022
    Article
  13. Article
  14. Article
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  16. Responsiveness of Retinal Ganglion Cells Through Frequency Modulation of Electrical Stimulation: A Computational Modeling StudyAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Tianruo GuoGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
David TsaiGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
Chih Yu YangGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
Amr Al AbedGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
Perry TwyfordVA Boston Healthcare System, Boston, MA, United States.
Shelley I FriedVA Boston Healthcare System, Boston, MA, United States.
John W MorleySchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Gregg J SuaningGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
Socrates DokosGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
Nigel H LovellGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.
UNSW Sydney · AUVA Boston Healthcare System · USWestern Sydney University · AU

Funding

Micro-coil implants for cortical activationU01NS099700 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2016 to 2018
$2.9M
Informing the Sub-Retinal Approach to Stimualation of the Retina.I01RX000350 · VA · VA BOSTON HEALTH CARE SYSTEM · PI FRIED, SHELLEY · 2011 to 2014
–
NINDS NIH HHS U01 NS099700RRD VA I01 RX000350RRD VA I01 RX001663
6 · The paper itself

Abstract

Recent retinal studies have directed more attention to sophisticated stimulation strategies based on high-frequency (>1.0 kHz) electrical stimulation (HFS). In these studies, each retinal ganglion cell (RGC) type demonstrated a characteristic stimulus-strength-dependent response to HFS, offering the intriguing possibility of focally targeting retinal neurons to provide useful visual information by retinal prosthetics. Ionic mechanisms are known to affect the responses of electrogenic cells during electrical stimulation. However, how these mechanisms affect RGC responses is not well understood at present, particularly when applying HFS. Here, we investigate this issue via an

Indexed as

computational modelinghigh-frequency electrical stimulationin vitro patch-clampneuromodulationretinal ganglion cellretinal implant

Identifiers

PMID31114476
PMCPMC6503046
OpenAlexW2942694457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.