ReviewNeuropsychiatric disease and treatment2019
Deep brain stimulation in Tourette's syndrome: evidence to date.
Review in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Advances in the application of temporal interference stimulation: a scoping review.Frontiers in human neuroscience · 2025Pooled it
- Anteromedial Globus Pallidus Internus Deep Brain Stimulation for Gilles de la Tourette Syndrome: A Two-Case Report and Review of the Literature.Neurology international · 2026Article
- From Pharmacological Treatment to Neuromodulation: A Comprehensive Approach to Managing Gilles de la Tourette Syndrome.International journal of molecular sciences · 2025Review
- Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications.Annals of medicine and surgery (2012) · 2025Review
- Dual bilateral stimulation of the nucleus accumbens and the centromedian thalamus for treatment of intractable Tourette syndrome.Surgical neurology international · 2025Article
- Correlating clinical course with baseline subcortical shape in provisional tic disorder.CNS spectrums · 2024Article
- Ethics of deep brain stimulation for neuropsychiatric disorders.Neurosurgical review · 2024Review
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- DiMANI: diffusion MRI for anatomical nuclei imaging-Application for the direct visualization of thalamic subnuclei.Frontiers in human neuroscience · 2024Article
- Microlesion Effect Induced by Electrode Implantation in the Posteroventral Globus Pallidus Interna for Severe Dystonic Tics.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2023Review
- Dual-Target Deep Brain Stimulation for Obsessive-Compulsive Disorder and Tourette Syndrome.Biological psychiatry · 2023Article
- Mapping whole brain effects of infrared neural stimulation with positron emission tomography.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Optogenetic Low-Frequency Stimulation of Principal Neurons, but Not Parvalbumin-Positive Interneurons, Prevents Generation of Ictal Discharges in Rodent Entorhinal Cortex in an In Vitro 4-Aminopyridine Model.International journal of molecular sciences · 2022Article
- Review
- Tics and Tourette Syndrome: A Literature Review of Etiological, Clinical, and Pathophysiological Aspects.Cureus · 2022Review
- Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults.Brain and behavior · 2022Article
- Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature.Current neurology and neuroscience reports · 2022Review
- Editorial: Deep brain stimulation for neuropsychiatric disorders: Current status and perspectives.Frontiers in neurology · 2022Article
- TikTok Tourette's: Are We Witnessing a Rise in Functional Tic-Like Behavior Driven by Adolescent Social Media Use?Psychology research and behavior management · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tourette's syndrome (TS) is a neurodevelopmental disorder that comprises vocal and motor tics associated with a high frequency of psychiatric comorbidities, which has an important impact on quality of life. The onset is mainly in childhood and the symptoms can either fade away or require pharmacological therapies associated with cognitive-behavior therapies. In rare cases, patients experience severe and disabling symptoms refractory to conventional treatments. In these cases, deep brain stimulation (DBS) can be considered as an interesting and effective option for symptomatic control. DBS has been studied in numerous trials as a therapy for movement disorders, and currently positive data supports that DBS is partially effective in reducing the motor and non-motor symptoms of TS. The average response, mostly from case series and prospective cohorts and only a few controlled studies, is around 40% improvement on tic severity scales. The ventromedial thalamus has been the preferred target, but more recently the globus pallidus internus has also gained some notoriety. The mechanism by which DBS is effective on tics and other symptoms in TS is not yet understood. As refractory TS is not common, even reference centers have difficulties in performing large controlled trials. However, studies that reproduce the current results in larger and multicenter randomized controlled trials to improve our knowledge so as to support the best target and stimulation settings are still lacking. This article will discuss the selection of the candidates, DBS targets and mechanisms on TS, and clinical evidence to date reviewing current literature about the use of DBS in the treatment of TS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.