ArticleNeuropsychiatric disease and treatment2019
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio.Frontiers in psychiatry · 2026Article
- The Relationship Between Cerebral Small Vessel Disease, Sleep Quality, and Cognitive Impairment Among Community-Dwelling Older Adults: Exploring the Role of Glymphatic Function.European journal of neurology · 2025Article
- Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.Scientific reports · 2025Article
- Relationship between cortical activation and sleep quality in cerebral small vessel disease patients: a functional near-infrared spectroscopy (fNIRS) study.Frontiers in neurology · 2025Article
- Differences in Gray Matter Volume in Cerebral Small Vessel Disease Patients with and without Sleep Disturbance.Brain sciences · 2023Article
- Neuropsychiatric symptoms and altered sleep quality in cerebral small vessel disease.Frontiers in psychiatry · 2022Article
- Association of Excessive Daytime Sleepiness with Cerebral Small Vessel Disease in Community-Dwelling Older Adults.Nature and science of sleep · 2022Article
- Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study.Frontiers in aging neuroscience · 2021Article
- Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer's Disease?Frontiers in physiology · 2021Review
- Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study.BMC neurology · 2020Article
- Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease.Nature and science of sleep · 2020Article
- Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia.Frontiers in psychiatry · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment in patients with cerebral small vessel disease (CSVD) is common, but the pathogenic mechanism is not well understood. The situation of non-breathing-related sleep fragmentation in CSVD patients and its influence on cognitive impairment is not clear. The aim of this study was to investigate the influence of non-breathing-related sleep fragmentation on cognitive function in patients with CSVD.
methodsA group of 89 CSVD patients without breathing-related sleep disorders in the Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University was enrolled. The patients underwent magnetic resonance scan, polysomnography, cognitive function evaluation using Montreal Cognitive Assessment scale (MoCA), and Mini-Mental State Examination. The patients were assigned to study group (arousal index [ArI] ≥26.8/hour) or control group (ArI <26.8/hour) based on the average level of ArI (mean =26.8, SD =7.5) at night, and the cognitive function of the patients in the two groups was analyzed.
resultsThe total MoCA score, the subscale scores of visuospatial ability and delayed recall in the study group were significantly lower than that in the control group (
conclusionNon-breathing-related sleep fragmentation is associated with cognitive impairment in CSVD patients, especially executive function and delayed recall ability.
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