ArticleInternational journal of nanomedicine2019
Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats.
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Article
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- Rutin attenuates complete Freund's adjuvant-induced inflammatory pain in rats.Iranian journal of basic medical sciences · 2025Article
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- Antioxidant and Hypoglycemic Potential of Phytogenic Selenium Nanoparticle- and Light Regime-MediatedACS omega · 2024Article
- Histopathological, Immunohistochemical, Biochemical, and In Silico Molecular Docking Study of Fungal-Mediated Selenium Oxide Nanoparticles onMicroorganisms · 2023Article
- Injection of Cerium Oxide Nanoparticles to Treat Spinal Cord Injury in Rats.Journal of neuropathology and experimental neurology · 2022Article
- Foliar Application of Cerium Oxide-Salicylic Acid Nanoparticles (CeOInternational journal of molecular sciences · 2022Article
- Evaluation of Antiarthritic and Antinociceptive Effects of Cedrol in a Rat Model of Arthritis.Oxidative medicine and cellular longevity · 2022Article
- Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights.Molecules (Basel, Switzerland) · 2021Review
- Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye.International journal of molecular sciences · 2021Review
- The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration.Cells · 2021Review
- Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering.Materials (Basel, Switzerland) · 2020Review
- Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2020Review
- Nitroxide-Modified Protein-Incorporated Nanoflowers with Dual Enzyme-Like Activities.International journal of nanomedicine · 2020Article
- Recent progress of nanomedicine in managing dry eye disease.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. PATIENTS AND
methodsThirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured.
resultsThe results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status.
conclusionAcute administration of pullulan-mediated CNPs is safe and possess antioxidant activity.
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Registered trials
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