Evidence map›Paper›PMID 31114134›Full record

ArticleWorld journal of gastroenterology2019

Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease.

Jing Zhou, Lu-Yi Wu, Liu Chen, Ya-Jing Guo, Yi Sun, Tao Li, Ji-Meng Zhao, Chun-Hui Bao, Huan-Gan Wu, Yin Shi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. A20 as a Potential Therapeutic Target for COVID-19.Immunity, inflammation and disease · 2025
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jing ZhouGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lu-Yi WuQigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
Liu ChenGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ya-Jing GuoGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yi SunGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Tao LiGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ji-Meng ZhaoKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chun-Hui BaoKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Huan-Gan WuKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yin ShiKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. flysy0636@163.com.
Shanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA20 inhibits intestinal epithelial cell apoptosis in Crohn's disease, and herbs-partitioned moxibustion (HPM) has been demonstrated to be an effective treatment for Crohn's disease. However, the mechanism by which HPM reduces intestinal epithelial cell apoptosis in Crohn's disease has not been thoroughly elucidated to date.

aimTo elucidate whether HPM exerts its effects by upregulating A20 to affect intestinal epithelial cell apoptosis in a Crohn's disease mouse model.

methodsIn this study, mice with A20 deletion in intestinal epithelial cells (A20

resultsThe intestinal epithelial barrier was noted to have an improvement in the HPM group of wild-type (WT) mice compared with that in A20

conclusionOur findings suggest that HPM in treating Crohn's disease functions possibly via upregulation of the A20 expression level, resulting in downregulation of TNFR1, TRADD, and RIP1 to alleviate increased cell apoptosis in the intestinal epithelial barrier in Crohn's disease.

Indexed as

MoxibustionAnimalsApoptosisColonCrohn DiseaseDisease Models, AnimalEpithelial CellsGene Expression ProfilingGTPase-Activating ProteinsIntestinal MucosaMesalamineMiceMice, Inbred C57BLPermeabilityReceptors, Tumor Necrosis Factor, Type ITNF Receptor-Associated Death Domain ProteinGTPase-Activating ProteinsMesalamineRalbp1 protein, mouseReceptors, Tumor Necrosis Factor, Type ITnfaip3 protein, mouseTNF Receptor-Associated Death Domain ProteinTnfrsf1a protein, mouseTradd protein, mouseTrinitrobenzenesulfonic AcidTumor Necrosis Factor alpha-Induced Protein 3A20Apoptotic pathwayCrohn’s diseaseHerbs-partitioned moxibustionInflammation

Identifiers

PMID31114134
PMCPMC6506586
OpenAlexW2944418822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.