Evidence map›Paper›PMID 31114131›Full record

ReviewWorld journal of gastroenterology2019

Recent advances in gastric cancer early diagnosis.

Laura Necula, Lilia Matei, Denisa Dragu, Ana I Neagu, Cristina Mambet, Saviana Nedeianu, Coralia Bleotu, Carmen C Diaconu, Mihaela Chivu-Economescu

Registry-linked trialAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05010863 (Gastric Cancer Marker Detection and Its Kit Development), which is not on this map. Cited by 255 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05010863 recruitingnot on this mapstarted 2021, after this paper: background citation

Gastric Cancer Marker Detection and Its Kit Development

Typeobservational_patient_registrySponsorSecond Affiliated Hospital of Wenzhou Medical UniversityRan2021 to 2030Enrolled530ConditionsGastric CancerArmsBlood collection
3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura NeculaDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Lilia MateiDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Denisa DraguDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Ana I NeaguDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Cristina MambetDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Saviana NedeianuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Coralia BleotuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Carmen C DiaconuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania.
Mihaela Chivu-EconomescuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania. mihaela.chivu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva, stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC.

Indexed as

Biomarkers, TumorCell-Free Nucleic AcidsDNA MethylationEarly Detection of CancerEndoscopyGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansMicroRNAsNeoplastic Cells, CirculatingPrognosisProteomeProteomicsRNA, Long NoncodingSensitivity and SpecificityStomachBiomarkers, TumorCell-Free Nucleic AcidsMicroRNAsProteomeRNA, Long NoncodingBiomarkersCirculating moleculesEarly diagnosisGastric cancerGenetic and epigenetic alterations

Identifiers

PMID31114131
PMCPMC6506585

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.