Evidence map›Paper›PMID 31114038›Full record

ReviewNature reviews. Immunology2019

Regulation of immune responses by tuft cells.

Christoph Schneider, Claire E O'Leary, Richard M Locksley

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 260 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. DNA methylation site loss for plasticity-led novel trait genetic fixation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. A Tuft Cell-Dependent Pathway Linking Intestinal and Cognitive Health.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christoph SchneiderDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Claire E O'LearyDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Richard M LocksleyDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA. richard.locksley@ucsf.edu.ORCID http://orcid.org/0000-0002-5468-6867
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
TRAINING PROGRAM IN DISGESTIVE DISEASES AND NUTRITIONT32DK007007 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AVERIL I MA · 1986 to 2026
$6.4M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
NHLBI NIH HHS P01 HL107202NIAID NIH HHS R01 AI026918NIDDK NIH HHS T32 DK007007
6 · The paper itself

Abstract

Tuft cells are rare, secretory epithelial cells that generated scant immunological interest until contemporaneous reports in 2016 linked tuft cells with type 2 immunity in the small intestine. Tuft cells have the capacity to produce an unusual spectrum of biological effector molecules, including IL-25, eicosanoids implicated in allergy (such as cysteinyl leukotrienes and prostaglandin D

Indexed as

AcetylcholineAnimalsCell LineageEicosanoidsHumansInterleukin-17Intestinal MucosaIntestine, SmallReceptors, G-Protein-CoupledSignal TransductionSuccinic AcidAcetylcholineEicosanoidsIL25 protein, humanInterleukin-17Receptors, G-Protein-CoupledSuccinic Acid

Identifiers

PMID31114038
PMCPMC8331098
OpenAlexW2946627380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.