ArticleScientific reports2019
Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 20 citations in OpenAlex.
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- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- A highly accurate quantum optimization algorithm for CT image reconstruction based on sinogram patterns.Scientific reports · 2023Article
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- Chronically Implanted Microelectrodes CauseFrontiers in neuroscience · 2019Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural probes provide many options for neuroscientific research and medical purposes. However, these implantable micro devices are not functionally stable over time due to host-probe interactions. Thus, reliable high-resolution characterization methods are required to understand local tissue changes upon implantation. In this work, synchrotron X-ray tomography is employed for the first time to image the interface between brain tissue and an implanted neural probe, showing that this 3D imaging method is capable of resolving probe and surrounding tissue at a resolution of about 1 micrometer. Unstained tissue provides sufficient contrast to identify electrode sites on the probe, cells, and blood vessels within tomograms. Exemplarily, we show that it is possible to quantify characteristics of the interaction region between probe and tissue, like the blood supply system. Our first-time study demonstrates a way for simultaneous 3D investigation of brain tissue with implanted probe, providing information beyond what was hitherto possible.
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