Evidence map›Paper›PMID 31113945›Full record

ArticleNature communications2019

Pheomelanin pigment remnants mapped in fossils of an extinct mammal.

Phillip L Manning, Nicholas P Edwards, Uwe Bergmann, Jennifer Anné, William I Sellers, Arjen van Veelen, Dimosthenis Sokaras, Victoria M Egerton, Roberto Alonso-Mori, Konstantin Ignatyev and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. From melanogenesis to melanin technologies.Communications chemistry · 2025
    Review
  3. Reduction of oxidative rancidification of fungal melanin-coated films in pork lard preservation in trading.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
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  9. Review
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  13. Transcriptomic and genomic changes associated with radioadaptation inComputational and structural biotechnology journal · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Recent advances in amniote palaeocolour reconstruction and a framework for future research.Biological reviews of the Cambridge Philosophical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Phillip L ManningUniversity of Manchester, School of Earth and Environmental Sciences, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-7161-6246
Nicholas P EdwardsStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Uwe BergmannStanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0001-5639-166X
Jennifer AnnéThe Children's Museum of Indianpolis, 3000 N Meridian St, Indianapolis, IN, 46208, USA.
William I SellersUniversity of Manchester, School of Earth and Environmental Sciences, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-2913-5406
Arjen van VeelenUniversity of Southampton, Faculty of Engineering and Physical Sciences, Southampton, SO17 1BJ, UK.
Dimosthenis SokarasStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Victoria M EgertonUniversity of Manchester, School of Earth and Environmental Sciences, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.
Roberto Alonso-MoriLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0002-5357-0934
Konstantin IgnatyevDiamond Light Source, Didcot, OX11 0DE, UK.ORCID http://orcid.org/0000-0002-8937-5655
Bart E van DongenUniversity of Manchester, School of Earth and Environmental Sciences, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.
Kazumasa WakamatsuDepartment of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, 470-1192, Japan.ORCID http://orcid.org/0000-0003-1748-9001
Shosuke ItoDepartment of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, 470-1192, Japan.
Fabien KnollUniversity of Manchester, School of Earth and Environmental Sciences, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-7822-8740
Roy A WogeliusUniversity of Manchester, School of Earth and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science & Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK. roy.wogelius@manchester.ac.uk.
University of Manchester · GBSLAC National Accelerator Laboratory · USFujita Health University · JPChildren's Museum of Indianapolis · USCollege of Charleston · USDiamond Light Source · GBUniversity of Southampton · GB

Funding

RCUK | Natural Environment Research Council (NERC) NE/J023426/1
6 · The paper itself

Abstract

Recent progress has been made in paleontology with respect to resolving pigmentation in fossil material. Morphological identification of fossilized melanosomes has been one approach, while a second methodology using chemical imaging and spectroscopy has also provided critical information particularly concerning eumelanin (black pigment) residue. In this work we develop the chemical imaging methodology to show that organosulfur-Zn complexes are indicators of pheomelanin (red pigment) in extant and fossil soft tissue and that the mapping of these residual biochemical compounds can be used to restore melanin pigment distribution in a 3 million year old extinct mammal species (Apodemus atavus). Synchotron Rapid Scanning X-ray Fluorescence imaging showed that the distributions of Zn and organic S are correlated within this fossil fur just as in pheomelanin-rich modern integument. Furthermore, Zn coordination chemistry within this fossil fur is closely comparable to that determined from pheomelanin-rich fur and hair standards. The non-destructive methods presented here provide a protocol for detecting residual pheomelanin in precious specimens.

Indexed as

Extinction, BiologicalFossilsAnimalsHairMelaninsMurinaeOptical ImagingPaleontologySpectrum AnalysisSulfurZincMelaninspheomelaninSulfurZinc

Identifiers

PMID31113945
PMCPMC6529433
OpenAlexW2945726621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.