ArticleTranslational psychiatry2019
Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism.Translational psychiatry · 2024Pooled it
- Augmenting extinction learning with D-cycloserine reduces return of fear: a randomized, placebo-controlled fMRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- The Role of Pavlovian Bias in Smoking Cessation Success and Neurocognitive Alterations During Nicotine Withdrawal.bioRxiv : the preprint server for biology · 2025Article
- Associations of COPhysiology & behavior · 2025Article
- Intra-individual comparison of appetitive trace and delay conditioning in humans across acquisition and extinction.Scientific reports · 2025Article
- Measuring Human Pavlovian Reward Conditioning and Memory Retention After Consolidation.Psychophysiology · 2025Article
- Testing a Reward-Processing Model of Negative Urgency in Women With and Without Binge Eating.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.Addiction biology · 2025Article
- Elevated Amygdala Responses During De Novo Pavlovian Conditioning in Alcohol Use Disorder Are Associated With Pavlovian-to-Instrumental Transfer and Relapse Latency.Biological psychiatry global open science · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- A systematic review of neural, cognitive, and clinical studies of anger and aggression.Current psychology (New Brunswick, N.J.) · 2022Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning.Frontiers in behavioral neuroscience · 2022Article
- Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning accounts of addiction and obesity emphasize the persistent power of Pavlovian reward cues to trigger craving and increase relapse risk. While extinction can reduce conditioned responding, Pavlovian relapse phenomena-the return of conditioned responding following successful extinction-challenge the long-term success of extinction-based treatments. Translational laboratory models of Pavlovian relapse could therefore represent a valuable tool to investigate the mechanisms mediating relapse, although so far human research has mostly focused on return of fear phenomena. To this end we developed an appetitive conditioning paradigm with liquid food rewards in combination with a 3-day design to investigate the return of appetitive Pavlovian responses and the involved neural structures in healthy subjects. Pavlovian conditioning (day 1) was assessed in 62 participants, and a subsample (n = 33) further completed extinction (day 2) and a reinstatement test (day 3). Conditioned responding was assessed on explicit (pleasantness ratings) and implicit measures (reaction time, skin conductance, heart rate, startle response) and reinstatement effects were further evaluated using fMRI. We observed a return of conditioned responding during the reinstatement test, evident by enhanced skin conductance responses, accompanied by enhanced BOLD responses in the amygdala. On an individual level, psychophysiological reinstatement intensity was significantly anticorrelated with ventromedial prefrontal cortex (vmPFC) activation, and marginally anticorrelated with enhanced amygdala-vmPFC connectivity during late reinstatement. Our results extend evidence from return of fear phenomena to the appetitive domain, and highlight the role of the vmPFC and its functional connection with the amygdala in regulating appetitive Pavlovian relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.